dc.contributor | JMI Labs | |
dc.contributor | Universidade Federal de São Paulo (UNIFESP) | |
dc.contributor | Tufts Univ | |
dc.creator | Sader, Helio Silva [UNIFESP] | |
dc.creator | Watters, A. A. | |
dc.creator | Fritsche, T. R. | |
dc.creator | Jones, R. N. | |
dc.date.accessioned | 2018-06-15T17:53:10Z | |
dc.date.accessioned | 2023-09-04T19:06:54Z | |
dc.date.available | 2018-06-15T17:53:10Z | |
dc.date.available | 2023-09-04T19:06:54Z | |
dc.date.created | 2018-06-15T17:53:10Z | |
dc.date.issued | 2008-02-01 | |
dc.identifier | Journal Of Chemotherapy. Florence: Esift Srl, v. 20, n. 1, p. 28-32, 2008. | |
dc.identifier | 1120-009X | |
dc.identifier | http://repositorio.unifesp.br/11600/44240 | |
dc.identifier | WOS:000254066100003 | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8622894 | |
dc.description.abstract | Daptomycin is a cyclic lipopeptide with potent bactericidal activity against Gram-positive organisms and has been approved by the United States Food and Drug Administration for the treatment of Staphylococcus aureus bacteremia and infectious endocarditis (right-side). We evaluated the activity of daptomycin against bloodstream infection S. aureus strains from 4,799 patients hospitalized in 32 medical centers (12 European countries, Turkey and Israel) with bloodstream infections (BSI) during a 5-year period (2002-2006). Intravenous catheters were the source of infection in 15% of cases, and those strains were analyzed separately. All strains were susceptibility tested by reference broth microdilution methods utilizing calcium supplementation (50 mg/L) when testing daptomycin. Bactericidal activity of daptomycin and vancomycin were evaluated against a subset of 50 randomly selected strains. Daptomycin (MIC (50/90), 0.25/0.5 mg/L), vancomycin (MIC50/90, 1/1 mg/L), and linezolid (MIC50/90, 2/2 mg/L), were highly active (>99.9% susceptibility) against the strains evaluated; and daptomycin was the most potent (lowest MIC90) among these compounds. Resistance rates to oxacillin and levofloxacin were generally elevated, especially when an intravenous catheter was the source of infection. | |
dc.language | eng | |
dc.publisher | Esift Srl | |
dc.relation | Journal Of Chemotherapy | |
dc.rights | Acesso restrito | |
dc.subject | daptomycin | |
dc.subject | vancomycin | |
dc.subject | linezolid | |
dc.subject | oxacillin | |
dc.subject | levofloxacin | |
dc.subject | bacteremia | |
dc.subject | endocarditis | |
dc.title | Activity of daptomycin and selected antimicrobial agents tested against Staphylococcus aureus from patients with bloodstream infections hospitalized in European medical centers | |
dc.type | Resenha | |