Resenha
Receptors coupling to G proteins: Is there a signal behind the sequence?
Fecha
2000-12-01Registro en:
Proteins-structure Function and Genetics. New York: Wiley-liss, v. 41, n. 4, p. 448-459, 2000.
0887-3585
10.1002/1097-0134(20001201)41:4<448
WOS:000165365500003
Autor
Horn, F.
van der Wenden, E. M.
Oliveira, Laerte [UNIFESP]
IJzerman, A. P.
Vriend, Gerrit
Institución
Resumen
Upon the binding of their ligands, G protein-coupled receptors couple to the heterotrimeric G proteins to transduce a signal. One receptor family may couple to a single G protein subtype and another family to several ones. Is there a signal in the receptor sequence that can give an indication of the G protein subtype selectivity? We used a sequence analysis method on biogenic amine and adenosine receptors and concluded that a weak signal can be detected in receptor families where specialization for coupling to a given G protein occurred during a recent divergent evolutionary process. Proteins 2000;41:448-459. (C) 2000 Wiley-Liss, Inc.