Experimental periodontal disease treatment by subgingival irrigation with tetracycline hydrochloride in rats

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorFernandes, Leandro Araujo
dc.creatorMartins, Thiago Marchi
dc.creatorAlmeida, Juliano Milanezi de
dc.creatorNagata, Maria José Hitomi
dc.creatorTheodoro, Letícia Helena
dc.creatorGarcia, Valdir Gouveia
dc.creatorBosco, Álvaro Francisco
dc.date2013-09-30T18:29:31Z
dc.date2014-05-20T13:43:18Z
dc.date2013-09-30T18:29:31Z
dc.date2014-05-20T13:43:18Z
dc.date2010-11-01
dc.date.accessioned2017-04-05T20:46:37Z
dc.date.available2017-04-05T20:46:37Z
dc.identifierJournal of Applied Oral Science. Bauru-sp: Univ São Paulo Fac Odontologia Bauru, v. 18, n. 6, p. 635-640, 2010.
dc.identifier1678-7757
dc.identifierhttp://hdl.handle.net/11449/15095
dc.identifierS1678-77572010000600017
dc.identifierWOS:000287143800016
dc.identifierS1678-77572010000600017-en.pdf
dc.identifierhttp://dx.doi.org/10.1590/S1678-77572010000600017
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/862158
dc.descriptionObjective: The aim of this study was to compare subgingival irrigation with tetracycline hydrochloride (TTC-HCL) as adjunctive treatment to scaling and root planning (SRP) on induced periodontitis in rats. Material and Methods: In 60 rats, periodontal disease was ligature-induced at the mandibular left first molar. After 7 days, the ligature was removed and all animals were submitted to SRP, and divided into 2 groups according to the following treatment: C (n=30) - subgingival irrigation with 1 mL of saline; T (n=30) - subgingival irrigation with 1 mL of TTC-HCL (50 mg/mL). Ten animals in each group were euthanized at 7, 15 and 30 days posttreatment. The histometric values were statistically analyzed (p<0.05). Results: In the histometric analysis, at 7, 15 and 30 days, Group T (0.72+/-0.05 mm(2), 0.57+/-0.14 mm(2), 0.62+/-0.07 mm(2)), showed less bone loss (p<0.05) than Group C (1.35+/-0.25 mm(2); 1.40+/-0.31 mm(2); 1.29+/-0.27 mm(2)), respectively. Conclusions: Subgingival irrigation with TTC-HCL was an effective adjunctive treatment for periodontal disease induced in rats.
dc.languageeng
dc.publisherUniversidade de São Paulo (USP), Faculdade de Odontologia de Bauru
dc.relationJournal of Applied Oral Science
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectIrrigation
dc.subjectPeriodontal diseases
dc.subjectPeriodontitis
dc.subjectRats
dc.subjectTetracycline
dc.titleExperimental periodontal disease treatment by subgingival irrigation with tetracycline hydrochloride in rats
dc.typeOtro


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