Cytokine Levels in Gestational Diabetes Mellitus: a Systematic Review of the Literature

dc.contributorUniversidade Federal de São Paulo (UNIFESP)
dc.creatorGomes, Caio Perez [UNIFESP]
dc.creatorTorloni, Maria Regina [UNIFESP]
dc.creatorGueuvoghlanian-Silva, Barbara Yasmin [UNIFESP]
dc.creatorAlexandre, Sandra Maria [UNIFESP]
dc.creatorMattar, Rosiane [UNIFESP]
dc.creatorDaher, Silvia [UNIFESP]
dc.date.accessioned2016-01-24T14:31:48Z
dc.date.accessioned2023-09-04T18:44:03Z
dc.date.available2016-01-24T14:31:48Z
dc.date.available2023-09-04T18:44:03Z
dc.date.created2016-01-24T14:31:48Z
dc.date.issued2013-06-01
dc.identifierAmerican Journal of Reproductive Immunology. Hoboken: Wiley-Blackwell, v. 69, n. 6, p. 545-557, 2013.
dc.identifier1046-7408
dc.identifierhttp://repositorio.unifesp.br/handle/11600/36364
dc.identifier10.1111/aji.12088
dc.identifierWOS:000318758800004
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8618383
dc.description.abstractProblem Gestational diabetes mellitus (GDM) is an inflammatory condition that involves unbalanced cytokine production. We carried out a systematic review on the relationship between GDM and maternal circulating levels of cytokines in the 2nd/3rd trimesters. Method of Study Three electronic databases (MEDLINE, EMBASE and LILACS), were searched. Duplicate study selection, extraction and quality assessment was performed. Results Twenty-two studies with 1982 participants reporting levels of 9 cytokines (IL-1B, IL-2, IL-6, IL-10, IL-13, IL-18, IFN-G, TGF-B and TNF-A) were included. Most studies differed considerably in selection criteria, sampling and assay methods and in reporting their results. Consequently, only two studies could be pooled: TNF-A concentration was slightly higher in GDM than in control patients, although not significant (WMD=0.45, 95% CI 0.341.23). Conclusions New studies with well-defined, more homogeneous methodological parameters are needed to detect whether there are significant differences in circulating levels of cytokines in patients with GDM.
dc.languageeng
dc.publisherWiley-Blackwell
dc.relationAmerican Journal of Reproductive Immunology
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.rightsAcesso aberto
dc.subjectBlood specimen collection
dc.subjectcytokines
dc.subjectgestational diabetes mellitus
dc.subjectinflammation
dc.subjectphysiopathology
dc.titleCytokine Levels in Gestational Diabetes Mellitus: a Systematic Review of the Literature
dc.typeResenha


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