Artigo
MOLECULAR-IDENTIFICATION of HEREDITARY PERSISTENCE of FETAL HEMOGLOBIN TYPE-2 (HPFH TYPE-2) in PATIENTS FROM BRAZIL
Fecha
1995-03-01Registro en:
Annals of Hematology. New York: Springer Verlag, v. 70, n. 3, p. 159-161, 1995.
0939-5555
10.1007/BF01682037
WOS:A1995QR57100008
Autor
Goncalves, M. S.
Fahel, S.
Figueiredo, M. S.
Kimura, E. J.
Nechtman, F.
Stoming, T. A.
Arruda, V. R.
Saad, STO
Costa, F. F.
Institución
Resumen
The HPFH deletion type 2 was first described in a patient from Ghana and is characterized by a large deletion of approximately 105 kb extension. We report here the results obtained in studying a black Brazilian patient who presented an association of beta-thalassemia and HPFH type 2, using a PCR strategy for detection of the breakpoint region. This procedure allows a rapid molecular identification of this condition and is a reliable procedure for screening patients with a hematological picture of HPFH deletion types.