Artigo
RELEASE of CONTRACTILE AGENTS FROM RAT VAS-DEFERENS BY CLONIDINE
Fecha
1991-01-01Registro en:
Life Sciences. Oxford: Pergamon-Elsevier B.V., v. 49, n. 22, p. 1643-1649, 1991.
0024-3205
10.1016/0024-3205(91)90059-K
WOS:A1991GL89600008
Autor
Jurkiewicz, N. H.
Jurkiewicz, A.
Institución
Resumen
Clonidine induces contractile effects on the isolated rat vas deferens, but not on rat uterus or guinea-pig ileum. However, we have observed that if clonidine is incubated for about 10 min with a nutrient solution containing an isolated rat vas deferens, the resulting solution can contract an isolated rat uterus, or guinea-pig ileum indicating the involvement of a substance released from the vas. This contractile effect was partially reduced by naloxone and by serotonin antagonists, and by using a denervated vas, indicating that opioids, serotonin and eventually other substances released from nerve tissue of the vas can be involved.