Artigo
CYTOGENETIC ASPECTS of WERNERS-SYNDROME LYMPHOCYTE-CULTURES
Fecha
1995-03-01Registro en:
Mechanisms of Ageing and Development. Clare: Elsevier Sci Publ Ireland Ltd, v. 78, n. 2, p. 117-122, 1995.
0047-6374
10.1016/0047-6374(94)01530-Y
WOS:A1995QP16400004
Autor
Melaragno, M. I.
Pagni, D.
Smith, MDC
Institución
Resumen
Lymphocyte cultures from five patients with Werner's syndrome (WS) and five healthy controls revealed significantly slower proliferation kinetics in four out of five patients. Higher frequencies of chromosome aberration and aneuploidy were also present with evidence of variegated translocation mosaicism in one of the patients. the study revealed no differences in sister chromatid exchange frequencies.