Effects of polymorphic microsatellites in the regulatory region of IGF1 and GHR on growth and carcass traits in beef cattle

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorCuri, Rogerio Abdallah
dc.creatorOliveira, H. N.
dc.creatorSilveira, Antonio Carlos
dc.creatorLopes, C. R.
dc.date2014-05-20T13:40:10Z
dc.date2016-10-25T16:55:39Z
dc.date2014-05-20T13:40:10Z
dc.date2016-10-25T16:55:39Z
dc.date2005-02-01
dc.date.accessioned2017-04-05T20:38:48Z
dc.date.available2017-04-05T20:38:48Z
dc.identifierAnimal Genetics. Oxford: Blackwell Publishing Ltd, v. 36, n. 1, p. 58-62, 2005.
dc.identifier0268-9146
dc.identifierhttp://hdl.handle.net/11449/13957
dc.identifierhttp://acervodigital.unesp.br/handle/11449/13957
dc.identifier10.1111/j.1365-2052.2004.01226.x
dc.identifierWOS:000226473100009
dc.identifierhttp://dx.doi.org/10.1111/j.1365-2052.2004.01226.x
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/861135
dc.descriptionGrowth hormone (GH), insulin-like growth factors 1 and 2 (IGF1 and IGF2) and their associated binding proteins and transmembrane receptors (GHR, IGF1R and IGF2R) play an important role in the physiology of mammalian growth. The objectives of the present study were to estimate the allele and genotype frequencies of microsatellite markers located in the 5'-regulatory region of the IGF1 and GHR genes in beef cattle belonging to different genetic groups and to determine effects of these markers on growth and carcass traits in these animals under an intensive production system. For this purpose, genotyping was performed on 384 bulls including 79 Nellore, 30 Canchim (5/8 Charolais + 3/8 Zebu) and 275 crossbred animals originating from crosses of Simmental (1/2 Simmental, n = 30) and Angus (1/2 Angus, n = 245) sires with Nellore females. The effects of substituting L allele for S allele of GHR microsatellite across Nellore, Canchim and 1/2 Angus were significant for weight gain and body weight (P < 0.05). The IGF1 microsatellite allele substitutions of 229 for 225 within Nellore group and of 225 for 229 within 1/2 Angus were not significant for any of the traits.
dc.languageeng
dc.publisherBlackwell Publishing
dc.relationAnimal Genetics
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectbeef cattle
dc.subjectcarcass
dc.subjectgrowth
dc.subjectmicrosatellite
dc.subjectpolymorphisms
dc.titleEffects of polymorphic microsatellites in the regulatory region of IGF1 and GHR on growth and carcass traits in beef cattle
dc.typeOtro


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