Effects of synbiotic-based Bifidobacterium animalis in female rats experimentally infected with Toxoplasma gondii

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorRibeiro, Claudia Mello
dc.creatorCosta, Veruska Maia
dc.creatorFranchi Vasconcelos Gomes, Maria Isabel
dc.creatorGolim, Marjorie Assis
dc.creatorModolo, José Rafael
dc.creatorLangoni, Hélio
dc.date2014-05-20T13:39:55Z
dc.date2016-10-25T16:55:30Z
dc.date2014-05-20T13:39:55Z
dc.date2016-10-25T16:55:30Z
dc.date2011-03-01
dc.date.accessioned2017-04-05T20:38:16Z
dc.date.available2017-04-05T20:38:16Z
dc.identifierComparative Immunology Microbiology and Infectious Diseases. Oxford: Elsevier B.V., v. 34, n. 2, p. 111-114, 2011.
dc.identifier0147-9571
dc.identifierhttp://hdl.handle.net/11449/13851
dc.identifierhttp://acervodigital.unesp.br/handle/11449/13851
dc.identifier10.1016/j.cimid.2010.03.002
dc.identifierWOS:000288718700003
dc.identifierhttp://dx.doi.org/10.1016/j.cimid.2010.03.002
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/861064
dc.descriptionThe aim of this study was to assess the effects of a synbiotic composed of Bifidobacterium animalis and fructooligosaccharides on female rats infected with Toxoplasma gondii. Female Wistar rats, treated or not with dexamethasone, were daily supplemented with synbiotics for 21 days. After 15 days of supplementation, the rats were orally infected with 10(4) T. gondii bradyzoites. Blood samples were collected to measure the levels of IFN-gamma, IL-10 and T. gondii antibodies. All synbiotic-supplemented rats survived until the end of the experiment; however, non-supplemented dexamethasone-treated rats died between the fifth and the eighth days after T. gondii infection. Dexamethasone-treated rats supplemented with synbiotics (P < 0.05) were capable of synthesizing IFN-gamma, and this immunological response was essential to ensure their survival. In addition, brain cysts were found in one rat not supplemented with synbiotics. Results suggest that the synbiotic composed of B. animalis and fructooligosaccharides may be beneficial to toxoplasmosis control. (C) 2010 Elsevier Ltd. All rights reserved.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationComparative Immunology Microbiology and Infectious Diseases
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSynbiotics
dc.subjectBifidobacterium animalis
dc.subjectInterferon-gamma
dc.subjectInterleukin-10
dc.subjectToxoplasma gondii
dc.titleEffects of synbiotic-based Bifidobacterium animalis in female rats experimentally infected with Toxoplasma gondii
dc.typeOtro


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