Effect of Mikania glomerata (Asteraceae) leaf extract combined with anti-venom serum on experimental Crotalus durissus (Squamata: Viperidae) envenomation in rats

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorFloriano, Rafael Stuani
dc.creatorBarilli Nogueira, Rosa Maria
dc.creatorSakate, Michiko
dc.creatorLaposy, Cecilia Braga
dc.creatorda Motta, Yudney Pereira
dc.creatorSangiorgio, Fabiola
dc.creatorDavid, Heloisa Costa
dc.creatorNabas, Joao Marcelo
dc.date2014-05-20T13:39:38Z
dc.date2016-10-25T16:55:19Z
dc.date2014-05-20T13:39:38Z
dc.date2016-10-25T16:55:19Z
dc.date2009-12-01
dc.date.accessioned2017-04-05T20:37:38Z
dc.date.available2017-04-05T20:37:38Z
dc.identifierRevista de Biologia Tropical. San Jose: Revista de Biologia Tropical, v. 57, n. 4, p. 929-937, 2009.
dc.identifier0034-7744
dc.identifierhttp://hdl.handle.net/11449/13747
dc.identifierhttp://acervodigital.unesp.br/handle/11449/13747
dc.identifierWOS:000272168100003
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/20073325
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/860986
dc.descriptionCrotalic envenomation represents the highest number of deaths when compared to other snakebite envenomations of medical interest. Crotalic venom has important characteristics such as neurotoxicity, myotoxicity, nephrotoxicity, and clotting and hemolytic action. We evaluated the clinical and laboratory aspects of Crotalus durissus terrificus experimental envenomation in Wistar rats treated with antivenom and the aqueous extract of the plant mikania glomerata. The animals were divided into three groups: Group C (control); Group VS-venom and antivenom; Group VSM-venom, antivenom and aqueous extract of M glomerata. Crotalic poison caused clinical and laboratory alterations in Wistar mice. Significant clinical alterations were: temperature decrease, edema in the venom inoculated member, sedation and a locomotion decrease in groups VS and VSM when compared with group C. A faster recovery from sedation was observed only for animals of group VSM when compared to VS. There was an increase in the number of leukocytes, neutrophils and creatine kinase in the VS and VSM groups, compared to group C. Wistar rats showed a high resistance to crotalic venom. Additional studies with different doses, time of treatment, different administration methods and histopathological and immunological studies are necessary to understand the action of M glomerata in crotalic accidents. Rev. Biol. Trop. 57 (4): 929-937. Epub 2009 December 01.
dc.languageeng
dc.publisherRevista de Biologia Tropical
dc.relationRevista de Biologia Tropical
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCrotalus durissus terrificus
dc.subjectMikania glomerata
dc.subjectantivenom
dc.subjectrat
dc.subjectvenom
dc.titleEffect of Mikania glomerata (Asteraceae) leaf extract combined with anti-venom serum on experimental Crotalus durissus (Squamata: Viperidae) envenomation in rats
dc.typeOtro


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