article
Association of BDNF Val66MET polymorphism with parkinson’s disease and depression and anxiety symptoms
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Autor
Godeiro Junior, Clécio de Oliveira
Cagni, Fernanda Carvalho
Campêlo, Clarissa Loureiro das Chagas
Coimbra, Daniel Gomes
Barbosa, Mayara Rodrigues
Oliveira Júnior, Luiz Gonzaga
Silva Neto, Antônio Braz
Ribeiro, Alessandra Mussi
Andrade, Tiago Gomes de
Silva, Regina Helena
Resumen
Parkinson’s disease (PD) is a progressive neurodegenerative disease that affects mainly dopaminergic neurons of the substantia nigra pars compacta (SNpc), leading to motor symptoms (tremor, bradykinesia, rigidity, and postural instability). PD also presents nonmotor symptoms, such as cognitive impairments and emotional disturbances (depression and anxiety). Although the direct cause is unknown, PD is a multifactorial disease influenced by environmental and genetic factors, with aging being the core predisposing factor.