Otro
Lapachol Induces Clastogenic Effects in Rats
Registro en:
Planta Medica. Stuttgart: Georg Thieme Verlag Kg, v. 76, n. 9, p. 858-862, 2010.
0032-0943
10.1055/s-0029-1240816
WOS:000279668400003
Autor
Maistro, Edson Luis
Fernandes, Diego Mota
Vieira Pereira, Fernanda Maria
Andrade, Sergio Faloni
Resumen
Lapachol is a naturally occurring naphthoquinone derivative found in the heartwood of several plants, particularly those of the genus Tabebuia (Bignoneaceae). Despite its use as a therapeutic product with anti-inflammatory, analgesic, anti-psoriatic, trypanocidal effects, among others, its in vivo mutagenic potential has still not been investigated. This paper reports the effects after a single oral administration of lapachol in the in vivo micronucleus (MN) and chromosome aberration (CA) assays. Both assays were performed using bone marrow cells from male Wistar rats. The animals were treated by oral gavage with hydro-alcoholic solutions of lapachol at the doses of 122, 244 and 365 mg/kg, chosen on the basis of the LD(50) in male rats. The results show that the higher administered lapachol dose induced a significant increase in the frequency of micro-nucleated polychromatic erythrocytes (MNPCE) and CAs in rat bone marrow cells, indicating that lapachol shows clastogenic effects under the experimental conditions used. Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)