Otro
Vibrational and Thermal Properties of Crystalline Topiramate
Registro en:
Journal of The Brazilian Chemical Society. São Paulo: Soc Brasileira Quimica, v. 19, n. 8, p. 1607-1613, 2008.
0103-5053
10.1590/S0103-50532008000800022
S0103-50532008000800022
WOS:000261658800022
Autor
Sena, Diniz M.
Freire, Paulo T. C.
Mendes Filho, Josue
Melo, Francisco E. A.
Pontes, Fenelon Martinho Lima
Longo, Elson
Ferreira, Odair P.
Alves, Oswaldo L.
Resumen
Topiramate, a powerful anticonvulsant drug, was investigated by X-ray diffractometry, FT-Raman, FT-IR, TGA and DTA techniques as well as by DFT calculations. From this study it was possible to tentatively assign most of the normal vibrational modes of the crystal. Thermal analysis from room temperature to 900 degrees C shows that the material does not present any structural phase transition and that the decomposition occurs in a two-step exothermic process. Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)