The reinstatement of amphetamine-induced place preference is long-lasting and related to decreased expression of AMPA receptors in the nucleus accumbens

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorCruz, F. C.
dc.creatorMarin, Marcelo Tadeu
dc.creatorPlaneta, Cleopatra da Silva
dc.date2014-05-20T13:25:33Z
dc.date2016-10-25T16:45:59Z
dc.date2014-05-20T13:25:33Z
dc.date2016-10-25T16:45:59Z
dc.date2008-01-24
dc.date.accessioned2017-04-05T20:03:20Z
dc.date.available2017-04-05T20:03:20Z
dc.identifierNeuroscience. Oxford: Pergamon-Elsevier B.V. Ltd, v. 151, n. 2, p. 313-319, 2008.
dc.identifier0306-4522
dc.identifierhttp://hdl.handle.net/11449/8105
dc.identifierhttp://acervodigital.unesp.br/handle/11449/8105
dc.identifier10.1016/j.neuroscience.2007.10.019
dc.identifierWOS:000252644600001
dc.identifierhttp://dx.doi.org/10.1016/j.neuroscience.2007.10.019
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/856579
dc.descriptionA great deal of effort has been devoted to elucidating the psychopharmacology underlying addiction and relapse. Long-term neuroadaptations in glutamate transmission seem to be of great relevance for relapse to stimulant abuse. In this study, we investigated amphetamine-induced conditioned place preference during adolescence and the reinstatement of the conditioned behavior following a priming injection of the drug 1 day (adolescence), 30 days (early adulthood) and 60 days (adulthood) after the extinction test. The nucleus accumbens was dissected immediately after the reinstatement test to examine alterations in GluR1 and NR1 subunits of glutamatergic receptors. Our results showed that a priming injection of amphetamine was able to reinstate the CPP 1 and 30 days after extinction. However, it failed to reinstate the conditioned response after 60 days. GluR1 levels were decreased on days 1 and 30 but not on day 60 while NR1 levels were unaltered in the reinstatement test. Using a relapse model we found that reinstatement of amphetamine-induced conditioning place preference during adolescence is long lasting and persists through early adulthood. Decreased levels of GluR1 in the nucleus accumbens might be related to the reinstatement of amphetamine-induced conditioning place preference. (C) 2008 IBRO. Published by Elsevier Ltd. All rights reserved.
dc.languageeng
dc.publisherPergamon-Elsevier B.V. Ltd
dc.relationNeuroscience
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectamphetamine
dc.subjectglutamate receptors
dc.subjectconditioned place preference
dc.subjectreinstatement
dc.subjectpsychostimulant
dc.subjectadolescent
dc.titleThe reinstatement of amphetamine-induced place preference is long-lasting and related to decreased expression of AMPA receptors in the nucleus accumbens
dc.typeOtro


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