This study aims to investigate the combined use of cognitive behavioral therapy (CBT) and the Psychopharmacotherapy in depression treatment. A bibliographic review that was carried out, looking for original works, bibliographic reviews, meta-analysis, and specialized textbooks. The combination of both therapies has been the first choice as a depression treatment in both mild and moderate patients and hospitalized patients classified with severe depression. The isolated use of antidepressants can lead to a discontinuation because of its side effects. The combine treatment increased the adherence and decreased the discontinuation rate of the therapy. The CBT as a solo treatment or combined with medication displayed superior efficiency rate than Psychopharmacological treatment alone. This research data suggests that CBT is essential in treatments with patients with chronic depression and with childhood traumas.