dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorChin, Chung Man
dc.creatorBosquesi, Priscila Longhin
dc.creatordos Santos, Jean Leandro
dc.date2014-05-20T13:24:52Z
dc.date2016-10-25T16:45:32Z
dc.date2014-05-20T13:24:52Z
dc.date2016-10-25T16:45:32Z
dc.date2011-11-01
dc.date.accessioned2017-04-05T20:01:34Z
dc.date.available2017-04-05T20:01:34Z
dc.identifierCurrent Pharmaceutical Design. Sharjah: Bentham Science Publ Ltd, v. 17, n. 32, p. 3515-3526, 2011.
dc.identifier1381-6128
dc.identifierhttp://hdl.handle.net/11449/7832
dc.identifierhttp://acervodigital.unesp.br/handle/11449/7832
dc.identifier10.2174/138161211798194512
dc.identifierWOS:000299637000005
dc.identifierhttp://dx.doi.org/10.2174/138161211798194512
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/856366
dc.descriptionIn therapeutics research, the nitro compounds are part of an important group of drugs with multiple pharmacological activities. However, in drug design, the inclusion of a nitro group in a molecule changes the physico-chemical and electronic properties and is associated with increased mutagenicity and carcinogenicity. In addition, several studies have related the relationship between the antimicrobial and/or anti-protozoal activity and the mutagenic effect to reduction of the nitro group. This work reviews the toxicity of nitro compounds and shows how the use of prodrugs can increase the biological activity and decrease the genotoxicity of nitro compounds, without any modification in nitro reduction behavior, but rather by physico-chemical improvement. Examples are given of metronidazole and nitrofurazone prodrugs.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageeng
dc.publisherBentham Science Publ Ltd
dc.relationCurrent Pharmaceutical Design
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectProdrugs
dc.subjectnitro-compounds
dc.subjectmetronidazol
dc.subjectnitrofurazone
dc.subjectgenotoxicity
dc.subjectphysico-chemical properties
dc.titleA Prodrug Approach to Improve the Physico-Chemical Properties and Decrease the Genotoxicity of Nitro Compounds
dc.typeOtro


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