Otro
Synthesis and in vitro anti Mycobacterium tuberculosis activity of a series of phthalimide derivatives
Registro en:
Bioorganic & Medicinal Chemistry. Oxford: Pergamon-Elsevier B.V. Ltd, v. 17, n. 11, p. 3795-3799, 2009.
0968-0896
10.1016/j.bmc.2009.04.042
WOS:000266117400007
Autor
Santos, Jean L.
Yamasaki, Paulo R.
Chin, Chung Man
Takashi, Celio H.
Pavan, Fernando Rogério
Leite, Clarice Queico Fujimura
Resumen
New phthalimide derivatives were easily prepared through condensation of phthalic anhydride and selected amines with variable yields (70-90%). All compounds (3a-l) were evaluated against Mycobacterium tuberculosis H(37)Rv using Alamar Blue susceptibility. The compounds 3c, 3i, and 3l have the minimum inhibitory concentrations (MICs) of 3.9, 7.8, and 5.0 mu/mL, respectively, and could be considered new lead compounds in the treatment of tuberculosis and multi-drug resistant tuberculosis. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved. Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)