Antimycobacterial activity of lichen substances

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorHonda, N. K.
dc.creatorPavan, Fernando Rogério
dc.creatorCoelho, R. G.
dc.creatorde Andrade Leite, S. R.
dc.creatorMicheletti, A. C.
dc.creatorLopes, T. I. B.
dc.creatorMisutsu, M. Y.
dc.creatorBeatriz, A.
dc.creatorBrum, R. L.
dc.creatorLeite, Clarice Queico Fujimura
dc.date2014-05-20T13:24:12Z
dc.date2016-10-25T16:44:56Z
dc.date2014-05-20T13:24:12Z
dc.date2016-10-25T16:44:56Z
dc.date2010-04-01
dc.date.accessioned2017-04-05T19:59:18Z
dc.date.available2017-04-05T19:59:18Z
dc.identifierPhytomedicine. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 17, n. 5, p. 328-332, 2010.
dc.identifier0944-7113
dc.identifierhttp://hdl.handle.net/11449/7438
dc.identifierhttp://acervodigital.unesp.br/handle/11449/7438
dc.identifier10.1016/j.phymed.2009.07.018
dc.identifierWOS:000276832000005
dc.identifierhttp://dx.doi.org/10.1016/j.phymed.2009.07.018
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/856080
dc.descriptionWe describe here the extraction and identification of several classes of phenolic compounds from the lichens Parmotrema dilatatum (Vain.) Hale, Parmotrema tinctorum (Nyl.) Hale, Pseudoparmelia sphaerospora (Nyl.) Hale and Usnea subcavata (Motyka) and determined their anti-tubercular activity. The depsides (atranorin, diffractaic and lecanoric acids), depsidones (protocetraric, salazinic, hypostictic and norstictic acids), xanthones (lichexanthone and secalonic acid), and usnic acid, as well seven orsellinic acid esters, five salazinic acid 8',9'-O-alkyl derivatives and four lichexanthone derivatives, were evaluated for their activity against Mycobacterium tuberculosis. Diffractaic acid was the most active compound (MIC value 15.6 mu g/ml, 41.6 mu M), followed by norstictic acid (MIC value 62.5 mu g/ml, 168 mu M) and usnic acid (MIC value 62.5 mu g/ml, 182 mu M). Hypostictic acid (MIC value 94.0 mu g/ml, 251 mu M) and protocetraric acid (MIC value 125 mu g/ml, 334 mu M) showed moderate inhibitory activity. The other compounds showed lower inhibitory activity on the growth of M. tuberculosis, varying from MIC values of 250 to 1370 mu M. (C) 2009 Elsevier GmbH. All rights reserved.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageeng
dc.publisherElsevier Gmbh, Urban & Fischer Verlag
dc.relationPhytomedicine
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMycobacterium tuberculosis
dc.subjectLichens
dc.subjectPhenolic products derivatives
dc.subjectTuberculostatic activity
dc.subjectDiffractaic acid
dc.titleAntimycobacterial activity of lichen substances
dc.typeOtro


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