dc.creatorSep?lveda, Beatriz
dc.creatorQuispe, Cristina
dc.creatorSimirgiotis, Mario
dc.creatorGarc?a-Beltr?n, Olimpo
dc.creatorAreche, Carlos
dc.date2019-03-11T21:20:21Z
dc.date2019-03-11T21:20:21Z
dc.date2016-07-15
dc.date.accessioned2023-08-31T19:21:33Z
dc.date.available2023-08-31T19:21:33Z
dc.identifierSep?lveda, B., Quispe, C., Simirgiotis, M., Garc?a-Beltr?n, O., & Areche, C. (2016). Gastroprotective effects of new diterpenoid derivatives from Azorella cuatrecasasii Mathias & Constance obtained using a ?-cyclodextrin complex with microbial and chemical transformations. Bioorganic & Medicinal Chemistry Letters, 26(14), 3220?3222.
dc.identifier0960-894X
dc.identifierhttps://www.sciencedirect.com/science/article/pii/S0960894X16305935?via%3Dihub
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8557314
dc.descriptionMulinane diterpenoids isolated from Azorella species have displayed gastroprotective effects in animal models. In this study we have transformed the main constituent, mulin-11,13-dien-20 oic acid from this plant using the filamentous fungus Mucor plumbeus and a ?-cyclodextrin inclusion complex and we have obtained two main products with good yields (33% and 15% for compound 4 and 5, respectively) for further preparation of semisynthetic derivatives to evaluate their gastroprotective effects. In addition, one of the compounds isolated from Azorella cuatrecasasii was new (9-epi-13?-hydroxymulinene 1). Six new derivatives 4a?4c and 5a?5c were then prepared by simple chemical transformations. The structures of all compounds were elucidated by spectroscopic means based on 1D and 2D-NMR techniques. Some 8 diterpenes were evaluated for their gastroprotective effects in the ethanol/HCl-induced ulcer model in mice at 20 mg/kg. The highest gastroprotective activity was shown by 7?,16-dihydroxymulin-11,13-dien-20-oic acid 5, which was higher than the reference drug lansoprazole, while 16-hydroxymulin-11,13-dien-20-oic acid 4 was as active as lansoprazole.
dc.languageen
dc.publisherBioorganic And Medicinal Chemistry Letters
dc.subjectAzorella cuatrecasasii
dc.subjectBiotransformation
dc.subjectMicrobial transformation
dc.subjectMulinane
dc.subjectGastric ulcer
dc.titleGastroprotective effects of new diterpenoid derivatives from Azorella cuatrecasasii Mathias & Constance obtained using a ?-cyclodextrin complex with microbial and chemical transformations
dc.typeArticle


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