| dc.creator | Sep?lveda, Beatriz | |
| dc.creator | Quispe, Cristina | |
| dc.creator | Simirgiotis, Mario | |
| dc.creator | Garc?a-Beltr?n, Olimpo | |
| dc.creator | Areche, Carlos | |
| dc.date | 2019-03-11T21:20:21Z | |
| dc.date | 2019-03-11T21:20:21Z | |
| dc.date | 2016-07-15 | |
| dc.date.accessioned | 2023-08-31T19:21:33Z | |
| dc.date.available | 2023-08-31T19:21:33Z | |
| dc.identifier | Sep?lveda, B., Quispe, C., Simirgiotis, M., Garc?a-Beltr?n, O., & Areche, C. (2016). Gastroprotective effects of new diterpenoid derivatives from Azorella cuatrecasasii Mathias & Constance obtained using a ?-cyclodextrin complex with microbial and chemical transformations. Bioorganic & Medicinal Chemistry Letters, 26(14), 3220?3222. | |
| dc.identifier | 0960-894X | |
| dc.identifier | https://www.sciencedirect.com/science/article/pii/S0960894X16305935?via%3Dihub | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8557314 | |
| dc.description | Mulinane diterpenoids isolated from Azorella species have displayed gastroprotective effects in animal models. In this study we have transformed the main constituent, mulin-11,13-dien-20 oic acid from this plant using the filamentous fungus Mucor plumbeus and a ?-cyclodextrin inclusion complex and we have obtained two main products with good yields (33% and 15% for compound 4 and 5, respectively) for further preparation of semisynthetic derivatives to evaluate their gastroprotective effects. In addition, one of the compounds isolated from Azorella cuatrecasasii was new (9-epi-13?-hydroxymulinene 1). Six new derivatives 4a?4c and 5a?5c were then prepared by simple chemical transformations. The structures of all compounds were elucidated by spectroscopic means based on 1D and 2D-NMR techniques. Some 8 diterpenes were evaluated for their gastroprotective effects in the ethanol/HCl-induced ulcer model in mice at 20 mg/kg. The highest gastroprotective activity was shown by 7?,16-dihydroxymulin-11,13-dien-20-oic acid 5, which was higher than the reference drug lansoprazole, while 16-hydroxymulin-11,13-dien-20-oic acid 4 was as active as lansoprazole. | |
| dc.language | en | |
| dc.publisher | Bioorganic And Medicinal Chemistry Letters | |
| dc.subject | Azorella cuatrecasasii | |
| dc.subject | Biotransformation | |
| dc.subject | Microbial transformation | |
| dc.subject | Mulinane | |
| dc.subject | Gastric ulcer | |
| dc.title | Gastroprotective effects of new diterpenoid derivatives from Azorella cuatrecasasii Mathias & Constance obtained using a ?-cyclodextrin complex with microbial and chemical transformations | |
| dc.type | Article | |
