Social separation and diazepam withdrawal increase anxiety in the elevated plus-maze and serotonin turnover in the median raphe and hippocampus

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorSantos, Lucinéia dos
dc.creatorAndrade, Telma Gonçalves Carneiro Spera de
dc.creatorGraeff, Frederico G.
dc.date2014-05-20T13:22:13Z
dc.date2016-10-25T16:43:30Z
dc.date2014-05-20T13:22:13Z
dc.date2016-10-25T16:43:30Z
dc.date2010-05-01
dc.date.accessioned2017-04-05T19:53:57Z
dc.date.available2017-04-05T19:53:57Z
dc.identifierJournal of Psychopharmacology. London: Sage Publications Ltd, v. 24, n. 5, p. 725-731, 2010.
dc.identifier0269-8811
dc.identifierhttp://hdl.handle.net/11449/6508
dc.identifierhttp://acervodigital.unesp.br/handle/11449/6508
dc.identifier10.1177/0269881109106954
dc.identifierWOS:000277324600012
dc.identifierhttp://dx.doi.org/10.1177/0269881109106954
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/855391
dc.descriptionThe present work aimed to evaluate the effects of social separation for 14 days (chronic stress) and of withdrawal from a 14-day treatment with diazepam (acute stress) on the exploratory behaviour of male rats in the elevated plus-maze and on serotonin (5-hydroxytryptamine) turnover in different brain structures. Social separation had an anxiogenic effect, evidenced by fewer entries into, and less time spent on the open arms of the elevated plus-maze. Separation also selectively increased 5-hydroxytryptamine turnover in the hippocampus and median raphe nucleus. Diazepam withdrawal had a similar anxiogenic effect in grouped animals and increased 5-hydroxytryptamine turnover in the same brain structures. Chronic treatment with imipramine during the 14 days of separation prevented the behavioural and neurochemical changes caused by social separation. It is suggested that the increase in anxiety determined by both acute and chronic stress is mediated by the activation of the median raphe nucleus-hippocampal 5-hydroxytryptamine pathway.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageeng
dc.publisherSage Publications Ltd
dc.relationJournal of Psychopharmacology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectsocial separation
dc.subjectanxiety
dc.subjectelevated plus-maze
dc.subjectserotonin
dc.subjectdiazepam withdrawal
dc.subjectimipramine
dc.titleSocial separation and diazepam withdrawal increase anxiety in the elevated plus-maze and serotonin turnover in the median raphe and hippocampus
dc.typeOtro


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