Mechanism of anticlastogenicity of Agaricus blazei Murill mushroom organic extracts in wild type CHO (K-1) and repair deficient (xrs5) cells by chromosome aberration and sister chromatid exchange assays

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorLuiz, R. C.
dc.creatorJordao, B. Q.
dc.creatorda Eira, A. F.
dc.creatorRibeiro, L. R.
dc.creatorMantovani, M. S.
dc.date2014-05-20T13:19:46Z
dc.date2016-10-25T16:41:20Z
dc.date2014-05-20T13:19:46Z
dc.date2016-10-25T16:41:20Z
dc.date2003-07-25
dc.date.accessioned2017-04-05T19:46:18Z
dc.date.available2017-04-05T19:46:18Z
dc.identifierMutation Research-fundamental and Molecular Mechanisms of Mutagenesis. Amsterdam: Elsevier B.V., v. 528, n. 1-2, p. 75-79, 2003.
dc.identifier0027-5107
dc.identifierhttp://hdl.handle.net/11449/5296
dc.identifierhttp://acervodigital.unesp.br/handle/11449/5296
dc.identifier10.1016/S0027-5107(03)00098-8
dc.identifierWOS:000184535200008
dc.identifierhttp://dx.doi.org/10.1016/S0027-5107(03)00098-8
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/854429
dc.descriptionAgaricus blazei Murill is a medicinal mushroom native to Brazil. The present work assessed the clastogenic and anticlastogenic potential of organic extracts (ethanol and chloroform/methanol) from the lineage AB97/11 in chinese hamster CHO-K-1 (wild type) and CHO-xrs5 (repair deficient) cells using the chromosome aberration (CA) and sister chromatid exchange (SCE) assays. In these experimental conditions were observed: (a) anticlastogenic effect at concentrations of 0.06 and 0.09% of the EtOH extract and at the 0.03 and 0.06% concentrations of the C/MetOH extract in CHO-K-1; (b) absence of protector effect on CHO-xrs5 cells; and (c) absence of protector effect in the SCE assay. These results indicate that organic extracts of A. blazei lineage AB97/11 present bio-antimutagenic type protective activity. (C) 2003 Elsevier B.V. B.V. All rights reserved.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationMutation Research: Fundamental and Molecular Mechanisms of Mutagenesis
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAgaricus blazei Murril
dc.subjectchromosome aberration assay
dc.subjectsister chromatid exchange assay
dc.subjectCHO cells
dc.subjectmethyl methanesulphonate
dc.titleMechanism of anticlastogenicity of Agaricus blazei Murill mushroom organic extracts in wild type CHO (K-1) and repair deficient (xrs5) cells by chromosome aberration and sister chromatid exchange assays
dc.typeOtro


Este ítem pertenece a la siguiente institución