Tumor suppressor in lung cancer-1 (TSLC1) loss is common in many human cancers, including meningioma. In this study, we demonstrate that TSLC1 protein and RNA expression is lost in 60% to 65% of high-grade gliomas, and that TSLC1 reintroduction into glioma cells results in growth suppression. Moreover, Tslc1 loss in mice results in increased astrocyte proliferation in vivo and in vitro. These data indicate that TSLC1 functions as a glioma tumor suppressor. ©2006AAN Enterprises, Inc.Fil: Houshmandi, S.S.. Washington University in St. Louis; Estados UnidosFil: Surace, Ezequiel Ignacio. Washington University in St. Louis; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Zhang, H.B.. Washington University in St. Louis; Estados UnidosFil: Fuller, G.N.. University of Texas; Estados UnidosFil: Gutmann, D.H.. Washington University in St. Louis; Estados Unidos