| dc.creator | Byrne, Alana Brooke | |
| dc.creator | Garcia, Cybele | |
| dc.creator | Damonte, Elsa Beatriz | |
| dc.creator | Talarico, Laura Beatriz | |
| dc.date | 2022-01 | |
| dc.date.accessioned | 2023-08-31T00:27:59Z | |
| dc.date.available | 2023-08-31T00:27:59Z | |
| dc.identifier | http://hdl.handle.net/11336/200499 | |
| dc.identifier | Byrne, Alana Brooke; Garcia, Cybele; Damonte, Elsa Beatriz; Talarico, Laura Beatriz; Murine models of dengue virus infection for novel drug discovery; Informa Healthcare; Expert Opinion On Drug Discovery; 17; 4; 1-2022; 397-412 | |
| dc.identifier | 1746-0441 | |
| dc.identifier | 1746-0441 | |
| dc.identifier | CONICET Digital | |
| dc.identifier | CONICET | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8543452 | |
| dc.description | Introduction: Dengue virus (DENV) is the causative agent of the most prevalent human disease transmitted by mosquitoes in tropical and subtropical regions worldwide. At present, no antiviral drug is available and the difficulties to develop highly protective vaccines against the four DENV serotypes maintain the requirement of effective options for dengue chemotherapy. Areas covered: The availability of animal models that reproduce human disease is a very valuable tool for the preclinical evaluation of potential antivirals. Here, the main murine models of dengue infection are described, including immunocompetent wild-type mice, immunocompromised mice deficient in diverse components of the interferon (IFN) pathway and humanized mice. The main findings in antiviral testing of DENV inhibitory compounds in murine models are also presented. Expert opinion: At present, there is no murine model that fully recapitulates human disease. However, immunocompromised mice deficient in IFN-α/β and -γ receptors, with their limitations, have shown to be the most suitable system for antiviral preclinical testing. In fact, the AG129 mouse model allowed the identification of celgosivir, an inhibitor of cellular glucosidases, as a promising option for DENV therapy. However, clinical trials still were not successful, emphasizing the difficulties in the transition from preclinical testing to human treatment. | |
| dc.description | Fil: Byrne, Alana Brooke. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez". Departamento de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | |
| dc.description | Fil: Garcia, Cybele. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina | |
| dc.description | Fil: Damonte, Elsa Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina | |
| dc.description | Fil: Talarico, Laura Beatriz. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez". Departamento de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina | |
| dc.format | application/pdf | |
| dc.format | application/pdf | |
| dc.format | application/pdf | |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | Informa Healthcare | |
| dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/17460441.2022.2033205 | |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/10.1080/17460441.2022.2033205 | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights | https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ | |
| dc.subject | AG129 MICE | |
| dc.subject | ANTIVIRAL | |
| dc.subject | DENGUE VIRUS | |
| dc.subject | HUMANIZED MICE | |
| dc.subject | IMMUNOCOMPETENT MICE | |
| dc.subject | MOUSE MODEL | |
| dc.subject | PRECLINICAL TESTING | |
| dc.subject | https://purl.org/becyt/ford/3.3 | |
| dc.subject | https://purl.org/becyt/ford/3 | |
| dc.title | Murine models of dengue virus infection for novel drug discovery | |
| dc.type | info:eu-repo/semantics/article | |
| dc.type | info:ar-repo/semantics/artículo | |
| dc.type | info:eu-repo/semantics/publishedVersion | |
