info:eu-repo/semantics/article
Wild argentinian amaryllidaceae, a new renewable source of the acetylcholinesterase inhibitor galanthamine and other alkaloids
Registro en:
Ortiz, Javier Esteban; Berkov, Strahil; Pigni, Natalia Belen; Theoduloz, Cristina; Roitman, German; et al.; Wild argentinian amaryllidaceae, a new renewable source of the acetylcholinesterase inhibitor galanthamine and other alkaloids; Molecular Diversity Preservation International; Molecules; 17; 11; 11-2012; 13473-13482
1420-3049
CONICET Digital
CONICET
Autor
Ortiz, Javier Esteban
Berkov, Strahil
Pigni, Natalia Belen
Theoduloz, Cristina
Roitman, German
Tapia, Alejandro
Bastida, Jaume
Feresin, Gabriela Egly
Resumen
The Amaryllidaceae family is well known for its pharmacologically active alkaloids. An important approach to treat Alzheimer´s disease involves the inhibition of the enzyme acetylcholinesterase (AChE). Galanthamine, an Amaryllidaceae alkaloid, is an effective, selective, reversible, and competitive AChE inhibitor. This work was aimed at studying the alkaloid composition of four wild Argentinian Amarillydaceae species for the first time, as well as analyzing their inhibitory activity on acetylcholinesterase. Alkaloid content was characterized by means of GC-MS analysis. Chloroform basic extracts from Habranthus jamesonii, Phycella herbertiana, Rhodophiala mendocina and Zephyranthes filifolia collected in the Argentinian Andean region all contained galanthamine, and showed a strong AChE inhibitory activity (IC 50 between 1.2 and 2 μg/mL). To our knowledge, no previous reports on alkaloid profiles and AChEIs activity of wild Argentinian Amarillydaceae species have been publisihed. The demand for renewable sources of industrial products like galanthamine and the need to protect plant biodiversity creates an opportunity for Argentinian farmers to produce such crops. Fil: Ortiz, Javier Esteban. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina Fil: Berkov, Strahil. Universidad de Barcelona; España Fil: Pigni, Natalia Belen. Universidad de Barcelona; España. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Theoduloz, Cristina. Universidad de Talca; Chile Fil: Roitman, German. Universidad de Buenos Aires. Facultad de Agronomía; Argentina Fil: Tapia, Alejandro. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina Fil: Bastida, Jaume. Universidad de Barcelona; España Fil: Feresin, Gabriela Egly. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina