Soybean is the major source of vegetable protein in the world. It is produced over a wide range of latitudes, from the Canadian prairies and Northern Great Plains in the USA to tropical areas in the Brazilian Cerrados. This chapter evaluates the environmental (E) and genetic (G) factors regulating soybean development, growth, seed yield, and seed constituents, as influenced by management (M) practices as well. The chapter focuses on three major soybean-producing regions of the world (Corn Belt in USA, Brazilian Cerrados, and Argentinean Pampas), providing examples about how G × E × M interactions are exploited for regional and local adaptation. Opportunities for yield improvement and future research are highlighted.Fil: Grassini, Patricio. Universidad de Nebraska - Lincoln; Estados UnidosFil: Cafaro la Menza, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata; Argentina. Universidad de Nebraska - Lincoln; Estados UnidosFil: Rattalino Edreira, Juan Ignacio. Universidad de Nebraska - Lincoln; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata; ArgentinaFil: Monzon, Juan Pablo. Universidad de Nebraska - Lincoln; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata; ArgentinaFil: Tenorio, Fatima A.. Universidad de Nebraska - Lincoln; Estados UnidosFil: Specht. James E.. Universidad de Nebraska - Lincoln; Estados Unidos