info:eu-repo/semantics/article
Solid-state characterization of two polymorphic forms of R-albuterol sulfate
Autor
Palacios, M.A.
Cuffini, S.
Badini, R.
Karlsson, A.
Palacios, S.M.
Institución
Resumen
R-Albuterol (levalbuterol) is a drug used for asthma therapy and some formulations of it are in solid dosage forms. The aim of this work was to describe and characterize two polymorphic modifications of R-albuterol sulfate by means of typical structure-sensitive analytical techniques such as X-ray powder diffraction, FT-IR spectroscopy, visual and microscopic inspection, and DSC. Substantial differences were observed between the solid-state properties of the crystals, confirming the existence of at least two polymorphic forms for R-albuterol sulfate: Form I and Form II. Fil: Palacios, M.A. Agencia Córdoba Ciencia SE, Unidad CEPROCOR, Santa Maria de Punilla 5164, Cordoba, Argentina Fil: Cuffini, S. Agencia Córdoba Ciencia SE, Unidad CEPROCOR, Santa Maria de Punilla 5164, Cordoba, Argentina Fil: Badini, R. Agencia Córdoba Ciencia SE, Unidad CEPROCOR, Santa Maria de Punilla 5164, Cordoba, Argentina Fil: Karlsson, A. Facultad de Ciencias Exactas Físicas y Naturales, Universidad Nacional de Córdoba, 5000 Córdoba, Vélez Sarsfield 298, Argentina Fil: Palacios, S.M. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina