info:eu-repo/semantics/article
Enantiomeric resolution of albuterol sulfate by preferential crystallization
Autor
Palacios, Sara María
Palacio, Marcela A.
Institución
Resumen
Albuterol is a β2-adrenoceptor agonist prescribed for the treatment of bronchial asthma; it exists as a racemate and its bronchodilator activity resides in the (R)-isomer or levalbuterol. The aim of this study was to determine a methodology that would separate the enantiomers of albuterol by preferential crystallization after a conglomerate is identified within its derivatives. We found that albuterol sulfate behaves as a conglomerate showing the characteristic αx-value = 2 (mole fraction solubility ratio of racemate vs enantiomer), the V-shaped ternary phase diagram and the preferential crystallization by seeding with the pure enantiomer. On the basis of these characteristics, we separated the enantiomers by entrainment, and crystallizing out a saturated methanolic solution of albuterol sulfate at 15 °C. Fil: Palacios, Sara María. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina Fil: Palacio, Marcela A. Agencia Córdoba Ciencia SE, Unidad CEPROCOR, 5164, Santa Maria dePunilla, Cordoba, Argentina