Otro
First polymorphisms in JY-1 gene in cattle (Bos taurus indicus) and their association with sexual precocity and growth traits
Registro en:
Molecular Biology Reports. Dordrecht: Springer, v. 39, n. 12, p. 10105-10109, 2012.
0301-4851
10.1007/s11033-012-1884-5
WOS:000310586700014
Autor
Ferreira de Camargo, Gregorio Miguel
Cardoso, Diercles Francisco
Monsalves Gil, Fernanda Maria
Silva Fonseca, Patricia Dias da
Zetouni, Larissa
Braz, Camila Urbano
Freitas, Ana Claudia de
Pablos de Souza, Fabio Ricardo
Aspilcueta-Borquis, Rusbel Raul
Baldi, Fernando
Albuquerque, Lucia Galvão de
Almeida Regitano, Luciana Correia de
Tonhati, Humberto
Resumen
Protein JY-1 is a bovine oocyte-specific protein that regulates granulosa cell function and is involved in early embryonic development, influencing the chance of pregnancy. This study investigated molecular markers for the JY-1 gene. Seven SNPs were identified in exon 3 of the gene. The positions of the SNPs in the exon and the respective substitutions are: 163 (T/C), 281 (T/C), 321 (T/C), 532 (T/C), 652 (A/G), 679 (T/C), and 722 (G/C) (GenBank: JN592587 and JF262042.2). SNP 163 is located in a coding region and causes a proline-to-leucine substitution. The other SNPs are located in the 3'UTR region. SNPs 163, 281, 321, and 679 were genotyped in 297 Nellore heifers and the haplotypes were constructed. The haplotypes of JY-1 were not correlated with the traits studied at 5 %. Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)