Outbreak of a cluster with epidemic behavior due to Serratia marcescens after colistin administration in a hospital setting

dc.creatorMerkier, Andrea Karina
dc.creatorRodriguez, Cecilia
dc.creatorTogneri, Ana María
dc.creatorBrengi, Silvina P.
dc.creatorOsuna, Carolina
dc.creatorPichel, Mariana
dc.creatorCassini, Marcelo H
dc.creatorCentrón, Daniela
dc.date2021-01-26T15:37:36Z
dc.date2021-01-26T15:37:36Z
dc.date2013-07
dc.date.accessioned2023-08-29T20:09:07Z
dc.date.available2023-08-29T20:09:07Z
dc.identifier1098-660X
dc.identifierhttp://sgc.anlis.gob.ar/handle/123456789/2245
dc.identifier10.1128/JCM.03280-12
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8520520
dc.descriptionFil: Merkier, Andrea Karina. Consejo Nacional de Investigaciones Científicas y Tecnológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Microbiología y Parasitología Médica; Argentina.
dc.descriptionFil: Rodríguez, María Cecilia. Consejo Nacional de Investigaciones Científicas y Tecnológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Microbiología y Parasitología Médica; Argentina.
dc.descriptionFil: Togneri, Ana. Hospital Evita. Servicio de Infectología. Laboratorio de Bacteriología, Lanús; Argentina.
dc.descriptionFil: Brengi, Silvina. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
dc.descriptionFil: Osuna, Carolina. Hospital Evita. Servicio de Infectología. Laboratorio de Bacteriología, Lanús; Argentina.
dc.descriptionFil: Pichel, Mariana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
dc.descriptionFil: Cassini, Marcelo H. Universidad Nacional de Luján. Departamento de Ciencias Básicas. Grupo GEMA. Laboratorio de Biología del Comportamiento; Argentina.
dc.descriptionFil: Centrón, Daniela. Consejo Nacional de Investigaciones Científicas y Tecnológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Microbiología y Parasitología Médica; Argentina.
dc.descriptionSerratia marcescens causes health care-associated infections with important morbidity and mortality. Particularly, outbreaks produced by multidrug-resistant isolates of this species, which is already naturally resistant to several antibiotics, including colistin, are usually described with high rates of fatal outcomes throughout the world. Thus, it is important to survey factors associated with increasing frequency and/or emergence of multidrug-resistant S. marcescens nosocomial infections. We report the investigation and control of an outbreak with 40% mortality due to multidrug-resistant S. marcescens infections that happened from November 2007 to April 2008 after treatment with colistin for Acinetobacter baumannii meningitis was started at hospital H1 in 2005. Since that year, the epidemiological pattern of frequently recovered species has changed, with an increase of S. marcescens and Proteus mirabilis infections in 2006 in concordance with a significant decrease of the numbers of P. aeruginosa and A. baumannii isolates. A single pulsed-field gel electrophoresis (PFGE) cluster of S. marcescens isolates was identified during the outbreak. When this cluster was compared with S. marcescens strains (n = 21) from 10 other hospitals (1997 to 2010), it was also identified in both sporadic and outbreak isolates circulating in 4 hospitals in Argentina. In132::ISCR1::blaCTX-M-2 was associated with the multidrug-resistant cluster with epidemic behavior when isolated from outbreaks. Standard infection control interventions interrupted transmission of this cluster even when treatment with colistin continued in several wards of hospital H1 until now. Optimizing use of colistin should be achieved simultaneously with improved infection control to prevent the emergence of species naturally resistant to colistin, such as S. marcescens and P. mirabilis.
dc.formatpdf
dc.languageen
dc.relationJournal of clinical microbiology
dc.rightsopen
dc.sourceJournal of Clinical Microbiology 2013;51(7):2295-2302
dc.subjectSerratia marcescens
dc.subjectColistina
dc.subjectHospitales
dc.titleOutbreak of a cluster with epidemic behavior due to Serratia marcescens after colistin administration in a hospital setting
dc.typeArtículo


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