Outbreaks of Mycobacterium tuberculosis MDR strains differentially induce neutrophil respiratory burst involving lipid rafts, p38 MAPK and Syk

dc.creatorRomero, María Mercedes
dc.creatorBasile, Juan Ignacio
dc.creatorLópez, Beatriz
dc.creatorRitacco, Viviana
dc.creatorBarrera, Lucía
dc.creatorSasiain, María Del Carmen
dc.creatorAlemán, Mercedes
dc.date2021-01-22T19:24:53Z
dc.date2021-01-22T19:24:53Z
dc.date2014-05-16
dc.date.accessioned2023-08-29T20:09:07Z
dc.date.available2023-08-29T20:09:07Z
dc.identifier1471-2334
dc.identifierhttp://sgc.anlis.gob.ar/handle/123456789/2223
dc.identifier10.1186/1471-2334-14-262
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8520514
dc.descriptionFil: Romero, María M. Academia Nacional de Medicina. Instituto de Investigaciones Hematológicas Mariano R. Castex; Argentina.
dc.descriptionFil: Basile, Juan I. Academia Nacional de Medicina. Instituto de Investigaciones Hematológicas Mariano R. Castex; Argentina.
dc.descriptionFil: López, Beatriz. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
dc.descriptionFil: Ritacco, Viviana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
dc.descriptionFil: Barrera, Lucía. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
dc.descriptionFil: Sasiain, María Del Carmen. Academia Nacional de Medicina. Instituto de Medicina Experimental; Argentina.
dc.descriptionFil: Alemán, Mercedes. Academia Nacional de Medicina. Instituto de Investigaciones Hematológicas Mariano R. Castex; Argentina.
dc.descriptionNeutrophils (PMN) are the first cells to infiltrate the lung after infection, and they play a significant protective role in the elimination of pathogen, by releasing preformed oxidants and proteolytic enzymes from granules and generating ROS, thus limiting inflammation by succumbing to apoptosis. In a previous study, we found marked differences in ROS-induced apoptosis between two Mycobacterium tuberculosis (Mtb) strains, M and Ra, representative of widespread Mtb families in South America, i.e. Haarlem and Latin-American Mediterranean (LAM), being strain M able to generate further drug resistance and to disseminate aggressively.
dc.formatpdf
dc.languageen
dc.relationBMC infectious diseases
dc.rightsopen
dc.sourceBMC Infectious Diseases 2014;14:262
dc.subjectMycobacterium tuberculosis
dc.subjectTuberculosis
dc.subjectNeutrófilos
dc.titleOutbreaks of Mycobacterium tuberculosis MDR strains differentially induce neutrophil respiratory burst involving lipid rafts, p38 MAPK and Syk
dc.typeArtículo


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