Outbreaks of mycobacterium tuberculosis MDR strains induce high IL-17 T-cell response in patients with MDR tuberculosis that is closely associated with high antigen load

dc.creatorBasile, Juan Ignacio
dc.creatorGeffner, Laura
dc.creatorRomero, María Mercedes
dc.creatorBalboa, Luciana
dc.creatorSabio y García, Carmen Alejandra
dc.creatorRitacco, Viviana
dc.creatorGarcía, Ana
dc.creatorCuffré, Mónica
dc.creatorAbbate, Eduardo
dc.creatorLópez, Beatriz
dc.creatorBarrera, Lucía
dc.creatorAmbroggi, Marta
dc.creatorAlemán, Mercedes
dc.creatorSasiain, María C.
dc.creatorde la Barrera, Silvia
dc.date2021-01-22T19:31:27Z
dc.date2021-01-22T19:31:27Z
dc.date2011-10-01
dc.date.accessioned2023-08-29T20:09:06Z
dc.date.available2023-08-29T20:09:06Z
dc.identifier1537-6613
dc.identifierhttp://sgc.anlis.gob.ar/handle/123456789/2237
dc.identifier10.1093/infdis/jir460
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8520513
dc.descriptionFil: Basile, Juan I. Academia Nacional de Medicina. Instituto de Investigaciones Hematológicas Mariano R. Castex; Argentina.
dc.descriptionFil: Geffner, Laura J. Academia Nacional de Medicina. Instituto de Investigaciones Hematológicas Mariano R. Castex; Argentina.
dc.descriptionFil: Romero, María M. Academia Nacional de Medicina. Instituto de Investigaciones Hematológicas Mariano R. Castex; Argentina.
dc.descriptionFil: Balboa, Luciana. Academia Nacional de Medicina. Instituto de Investigaciones Hematológicas Mariano R. Castex; Argentina.
dc.descriptionFil: Sabio y García, Carmen. Academia Nacional de Medicina. Instituto de Investigaciones Hematológicas Mariano R. Castex; Argentina.
dc.descriptionFil: Ritacco, Viviana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
dc.descriptionFil: García, Ana. Hospital Muñíz. Instituto de Tisioneumonologías; Argentina.
dc.descriptionFil: Cuffré, Mónica. Hospital Muñíz. Instituto de Tisioneumonologías; Argentina.
dc.descriptionFil: Abbate, Eduardo. Hospital Muñíz. Instituto de Tisioneumonologías; Argentina.
dc.descriptionFil: López, Beatriz. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
dc.descriptionFil: Barrera, Lucía. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
dc.descriptionFil: Ambroggi, Marta. Hospital Muñíz. Instituto de Tisioneumonologías; Argentina.
dc.descriptionFil: Alemán, Mercedes. Academia Nacional de Medicina. Instituto de Investigaciones Hematológicas Mariano R. Castex; Argentina.
dc.descriptionFil: Sasiain, María C. Academia Nacional de Medicina. Instituto de Investigaciones Hematológicas Mariano R. Castex; Argentina.
dc.descriptionFil: de la Barrera, Silvia S. Academia Nacional de Medicina. Instituto de Investigaciones Hematológicas Mariano R. Castex; Argentina.
dc.descriptionBackground. The proinflammatory cytokine interleukin 17 (IL-17) plays an important role in immune responses but it is also associated with tissue-damaging inflammation. So, we evaluated the ability of Mycobacterium tuberculosis clinical isolates to induce IL-17 in tuberculosis (TB) patients and in healthy human tuberculin reactors (PPD1HD). Methods. IL-17, interferon c (IFN-c), and interleukin 23 (IL-23) receptor expression were evaluated ex vivo and cultured peripheral blood mononuclear cells from TB and PPD1HD stimulated with irradiated clinical isolates from multidrug resistant (MDR) outbreaks M (Haarlem family) and Ra (Latin American–Mediterranean family), as well as drug-susceptible isolates belonging to the same families and laboratory strain H37Rv for 48 hours in T-cell subsets by flow cytometry. Results. We observed that: (1) MDR strains M and Ra are stronger IL-17 inducers than drug-susceptible Mtb strains of the Haarlem and Latin American–Mediterranean families, (2) MDR-TB patients show the highest IL-17 expression that is independent on the strain, (3) IL-17 expression is dependent on CD41 and CD81 T cells associates with persistently high antigen load. Conclusions. IL-17–producing T cells could play an immunopathological role in MDR-TB promoting severe tissue damage, which may be associated with the low effectiveness of the second-line drugs employed in the treatment.
dc.formatpdf
dc.languageen
dc.relationThe Journal of infectious diseases
dc.rightsopen
dc.sourceThe Journal of Infectious Diseases 2011;204(7):1054-1064
dc.subjectMycobacterium tuberculosis
dc.subjectTuberculosis
dc.subjectInterleucina-17
dc.subjectLinfocitos T
dc.titleOutbreaks of mycobacterium tuberculosis MDR strains induce high IL-17 T-cell response in patients with MDR tuberculosis that is closely associated with high antigen load
dc.typeArtículo


Este ítem pertenece a la siguiente institución