Penicillin-resistant Streptococcus pneumoniae in Argentina: frequent occurrence of an internationally spread serotype 14 clone

dc.creatorRossi, Alicia
dc.creatorCorso, Alejandra
dc.creatorPace, J.
dc.creatorRegueira, Mabel
dc.creatorTomasz, Alexander
dc.date2021-01-21T18:25:17Z
dc.date2021-01-21T18:25:17Z
dc.date1998
dc.date.accessioned2023-08-29T20:09:02Z
dc.date.available2023-08-29T20:09:02Z
dc.identifier1076-6294
dc.identifierhttp://sgc.anlis.gob.ar/handle/123456789/2217
dc.identifier10.1089/mdr.1998.4.225
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8520475
dc.descriptionFil: Rossi, Alicia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología. Servicio Antimicrobianos; Argentina.
dc.descriptionFil: Corso, Alejandra. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología. Servicio Antimicrobianos; Argentina.
dc.descriptionFil: Pace, J. ANLIS Dr. C. G. Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología; Argentina.
dc.descriptionFil: Regueira, Mabel. ANLIS Dr. C. G. Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología; Argentina.
dc.descriptionFil: Tomasz, Alexander. Laboratory of Microbiology, The Rockefeller University, New York; Argentina.
dc.descriptionSix Latin-American countries participated in an epidemiological surveillance study conducted by the Pan American Health Organization in order to determine the relative prevalence of capsular types and antimicrobial resistance patterns of Streptococcus pneumoniae (SPN) causing invasive infections in children <5 years of age. In Argentina, the incidence of penicillin resistance (PR) was 24.4%, and it was significantly associated with serotype 14 (p < 0.001). The chromosomal DNA of 56 of those SPN isolates, 39 PR and 17 susceptible, was digested with SmaI and resolved by PFGE. Eighty-two percent (32/39) of the PR isolates shared characteristics with the widely spread International Spanish/French clone (clone B). All members of clone B except one expressed serotype 14, with the exception of one isolate that expressed serotype 19F and probably resulted from an in vivo capsular transformation event. Only a single isolate shared features with the 23F International Spanish/USA clone (clone A). The 17 penicillin-susceptible (PS) SPN isolates presented an enormous degree of variation in the chromosomal background, expressing 12 serotypes and 13 PFGE patterns. The data suggest that over 80% of the SPN-PR isolates in Argentina were imported, and this confirms the importance of the geographic spread of SPN clones in South America.
dc.formatpdf
dc.languageen
dc.relationMicrobial drug resistance (Larchmont, N.Y.)
dc.rightsnone
dc.sourceMicrobial Drug Resistance 1998;4(3):225-231
dc.subjectMeningitis Neumocócica
dc.subjectInfecciones Neumocócicas
dc.subjectStreptococcus pneumoniae
dc.subjectArgentina
dc.titlePenicillin-resistant Streptococcus pneumoniae in Argentina: frequent occurrence of an internationally spread serotype 14 clone
dc.typeArtículo


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