Biochemical characterization of the Micrurus pyrrhocryptus venom

dc.creatorDokmetjian, Christian
dc.creatorDel Canto, Sergio
dc.creatorVinzón, Sabrina
dc.creatorBiscoglio de Jiménez Bonino, Mirtha
dc.date2021-01-05T21:20:43Z
dc.date2021-01-05T21:20:43Z
dc.date2009-03-01
dc.date.accessioned2023-08-29T20:08:20Z
dc.date.available2023-08-29T20:08:20Z
dc.identifier0041-0101
dc.identifierhttp://sgc.anlis.gob.ar/handle/123456789/2040
dc.identifier10.1016/j.toxicon.2008.12.015
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8520121
dc.descriptionFil: Dokmetjian, Christian. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Producción de Biológicos; Argentina.
dc.descriptionFil: Del Canto, Sergio. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica. Instituto de Química y Fisicoquímica Biológicas; Argentina.
dc.descriptionFil: Vinzón, Sabrina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica. Instituto de Química y Fisicoquímica Biológicas; Argentina.
dc.descriptionFil: Biscoglio de Jiménez Bonino, Mirtha. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica. Instituto de Química y Fisicoquímica Biológicas; Argentina.
dc.descriptionSnake venom toxicity is the consequence of a combination of peptides and proteins whose identification and characterization are of great importance to understand envenomation and develop new clinical treatments. The Elapinae subfamily includes coral snakes whose bite causes mainly neurotoxic effects which disable muscle contraction and paralyse the heart as well as inhibit respiration. However, the structure-function relationship of venom toxins has been investigated only for a few species. We herein study biological aspects of the Micrurus pyrrhocryptus venom such as LD(50), hemorrhagic, necrotic, coagulant, myotoxic and hemolytic activity as well as the ability of venom components to compete with alpha-Bungarotoxin for the ligand-binding site of the nicotinic acetylcholine receptor. Besides, we report the determination of the molecular mass and N-terminal sequence of toxins including PLA2s, short, long and weak neurotoxins. The complete sequence of one of the short neurotoxins has also been obtained, this being the first sequence of an alpha-neurotoxin determined in the M. pyrrhocryptus venom and one of the few fully determined in members of the Micrurus genus.
dc.languageen
dc.relationToxicon : official journal of the International Society on Toxinology
dc.rightsnone
dc.subjectNeurotoxinas
dc.subjectHemorragia
dc.subjectVenenos Elapídicos
dc.subjectReceptores Nicotínicos
dc.subjectVenenos de Serpiente
dc.titleBiochemical characterization of the Micrurus pyrrhocryptus venom
dc.typeArtículo


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