Genetic characterization of hantaviruses associated with sigmodontine rodents in an endemic area for hantavirus pulmonary syndrome in southern Brazil

dc.creatorOliveira, Renata Carvalho de
dc.creatorPadula, Paula J
dc.creatorGomes, Raphael
dc.creatorMartínez, Valeria Paula
dc.creatorBellomo, Carla
dc.creatorBonvicino, Cibele R
dc.creatorFreire e Lima, Danúbia Inês
dc.creatorBragagnolo, Camila
dc.creatorCaldas, Antônio C S
dc.creatorD'Andrea, Paulo S
dc.creatorde Lemos, Elba R S
dc.date2020-12-23T15:39:25Z
dc.date2020-12-23T15:39:25Z
dc.date2011-03
dc.date.accessioned2023-08-29T20:08:09Z
dc.date.available2023-08-29T20:08:09Z
dc.identifierhttp://sgc.anlis.gob.ar/handle/123456789/1983
dc.identifier10.1089/vbz.2010.0001
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8520023
dc.descriptionFil: Oliveira, Renata Carvalho de. Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hantaviroses e Rickettsioses; Brasil.
dc.descriptionFil: Padula, Paula J. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
dc.descriptionFil: Fil: Gomes, Raphael. Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hantaviroses e Rickettsioses; Brasil.
dc.descriptionFil: Martínez, Valeria Paula. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
dc.descriptionFil: Bellomo, Carla. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
dc.descriptionFil: Bonvicino, Cibele R. Ministério da Saúde. Instituto Nacional de Câncer; Brasil.
dc.descriptionFil: Freire e Lima, Danúbia Inês. Instituto Oswaldo Cruz. Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios; Brasil.
dc.descriptionFil: Bragagnolo, Camila. Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hantaviroses e Rickettsioses; Brasil.
dc.descriptionFil: Caldas, Antônio C S. Secretaria de Estado de Saúde de Santa Catarina; Brasil.
dc.descriptionFil: D'Andrea, Paulo S. Instituto Oswaldo Cruz. Laboratório de Biologia e Parasitologia de Mamíferos Silvestres Reservatórios; Brasil.
dc.descriptionFil: de Lemos, Elba R S. Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hantaviroses e Rickettsioses; Brasil.
dc.descriptionAn ecological assessment of reservoir species was conducted in a rural area (Jaborá) in the mid-west of the state of Santa Catarina in southern Brazil, where hantavirus pulmonary syndrome is endemic, to evaluate the prevalence of hantavirus infection in wild rodents. Blood and tissue samples were collected from 507 rodents during seven field trips from March 2004 to April 2006. Some of the animals were karyotyped to confirm morphological identification. Phylogenetic reconstructions of rodent specimens, based on the mitochondrial DNA cytochrome b gene sequences, were also obtained. Hantavirus antibody was found in 22 (4.3%) of the 507 rodents: 5 Akodon montensis, 2 Akodon paranaensis, 14 Oligoryzomys nigripes, and 1 Sooretamys angouya. Viral RNAs detected in O. nigripes and A. montensis were amplified and sequenced. O. nigripes virus genome was 97.5% (nt) and 98.4% (nt) identical to sequences published for Araucaria (Juquitiba-like) virus based on N and G2 fragment sequences. Viral sequences from A. montensis strain showed 89% and 88% nucleotide identities in a 905-nt fragment of the nucleocapsid (N) protein-coding region of the S segment when it was compared with two other Akodontine rodent-associated viruses from Paraguay, A. montensis and Akodon cursor, respectively. Phylogenetic analysis showed the cocirculation of two genetic hantavirus lineages in the state of Santa Catarina, one from O. nigripes and the other from A. montensis, previously characterized in Brazil and Paraguay, respectively. The hantavirus associated with A. montensis, designed Jaborá virus, represents a distinct phylogenetic lineage among the Brazilian hantaviruses.
dc.languageen
dc.publisherMary Ann Liebert
dc.publisherSociety for Zoonotic Ecology and Epidemiology
dc.relation#PLACEHOLDER_PARENT_METADATA_VALUE#
dc.relationdatasets
dc.relationVector borne and zoonotic diseases (Larchmont, N.Y.)
dc.rightsnone
dc.sourceVector Borne and Zoonotic Diseases 2011; 11(3):301-14
dc.subjectAnimales
dc.subjectAnticuerpos Antivirales
dc.subjectSecuencia de Bases
dc.subjectBrasil
dc.subjectProteínas de la Cápside
dc.subjectCitocromos b
dc.subjectADN Mitocondrial
dc.subjectReservorios de Enfermedades
dc.subjectFemenino
dc.subjectVariación Genética
dc.subjectHantavirus
dc.subjectSíndrome Pulmonar por Hantavirus
dc.subjectMasculino
dc.subjectDatos de Secuencia Molecular
dc.subjectFilogenia
dc.subjectPrevalencia
dc.subjectARN Viral
dc.subjectEnfermedades de los Roedores
dc.subjectAnálisis de Secuencia de ADN
dc.subjectProteínas del Núcleo Viral
dc.subjectProteínas Virales
dc.subjectEnfermedades Endémicas
dc.subjectSigmodontinae
dc.titleGenetic characterization of hantaviruses associated with sigmodontine rodents in an endemic area for hantavirus pulmonary syndrome in southern Brazil
dc.typeArtículo


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