Artículo
Antimicrobial activity of de novo designed cationic peptides against multi-resistant clinical isolates
Registro en:
10.1016/j.ejmech.2013.10.065
Autor
Faccone, Diego
Veliz, Omar
Corso, Alejandra
Noguera, Martín Ezequiel
Martínez, Melina
Payes, Cristian
Semorile, Liliana
Maffía, Paulo Cesar
Resumen
Fil: Faccone, Diego. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Antimicrobianos; Argentina. Fil: Veliz, Omar. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Antimicrobianos; Argentina. Fil: Corso, Alejandra. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Antimicrobianos; Argentina. Fil: Noguera, Martin. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina. Fil: Martínez, Melina. Universidad Nacional de Quilmes. Laboratorio de Microbiología Molecular; Argentina. Fil: Payes, Cristian. Universidad Nacional de Quilmes. Laboratorio de Microbiología Molecular; Argentina. Fil: Semorile, Liliana. Universidad Nacional de Quilmes. Laboratorio de Microbiología Molecular; Argentina. Fil: Maffía, Paulo Cesar. Universidad Nacional de Quilmes. Laboratorio de Microbiología Molecular; Argentina. Antibiotic resistance is one of the main problems concerning public health or clinical practice. Antimicrobial peptides appear as good candidates for the development of new therapeutic drugs. In this study we de novo designed a group of cationic antimicrobial peptides, analyzed its physicochemical properties, including its structure by circular dichroism and studied its antimicrobial properties against a panel of clinical isolates expressing different mechanisms of resistance. Three cationic alpha helical peptides exhibited antimicrobial activity comparable to, or even better than the comparator omiganan (MBI-226).