Evaluation of the in vitro activity of amphotericin B by time-kill curve methodology against large and small capsulate C. neoformans isolates

Córdoba, Susana; Afeltra, Javier; Vitale, Roxana G

Artículo

Registro en:

http://sgc.anlis.gob.ar/handle/123456789/1896

10.1016/j.diagmicrobio.2011.08.003

https://repositorioslatinoamericanos.uchile.cl/handle/2250/8519853

Autor

Córdoba, Susana

Afeltra, Javier

Vitale, Roxana G

Institución

Administración Nacional de Laboratorios e Institutos de Salud (Argentina)

Resumen

Fil: Córdoba, Susana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micologia; Argentina.

Fil: Afeltra, Javier. Hospital Dr. José María Ramos Mejía. Micologia. Unidad de Parasitologia; Argentina.

Fil: Vitale, Roxana G. Hospital Dr. José María Ramos Mejía. Micologia. Unidad de Parasitologia; Argentina.

We have evaluated and compared the activity of amphotericin B (AMB) by time-kill curve methodology against 20 clinical Cryptococcus neoformans isolates in which capsule induction in vitro was performed. Overall, large capsulated isolates were more resistant to killing by AMB over time when compared with those small capsulate ones.

Materias

Anfotericina B

Antifúngicos

Cryptococcus neoformans

Humanos

Factores de Tiempo

Pruebas de Sensibilidad Microbiana

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