Genomics of the Argentinian cholera epidemic elucidate the contrasting dynamics of epidemic and endemic Vibrio cholerae

dc.creatorDorman, Matthew J
dc.creatorDomman, Daryl
dc.creatorPoklépovich, Tomás Javier
dc.creatorTolley, Charlotte
dc.creatorZolezzi, Gisela
dc.creatorKane, Leanne
dc.creatorViñas, María R.
dc.creatorPanagópulo, Marcela
dc.creatorMoroni, Miriam
dc.creatorBinsztein, Norma
dc.creatorCaffer, María Inés
dc.creatorClare, Simon
dc.creatorDougan, Gordon
dc.creatorSalmond, George P C
dc.creatorParkhill, Julian
dc.creatorCampos, Josefina
dc.creatorThomson, Nicholas R
dc.date2020-11-30T16:11:18Z
dc.date2020-11-30T16:11:18Z
dc.date2020-10-01
dc.date.accessioned2023-08-29T20:07:24Z
dc.date.available2023-08-29T20:07:24Z
dc.identifier2041-1723
dc.identifierhttp://sgc.anlis.gob.ar/handle/123456789/1775
dc.identifier10.1038/s41467-020-18647-7
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8519636
dc.descriptionFil: Dorman, Matthew J. Wellcome Genome Campus. Wellcome Sanger Institute, Hinxton; Reino Unido.
dc.descriptionFil: Domman, Daryl. Wellcome Genome Campus. Wellcome Sanger Institute, Hinxton; Reino Unido.
dc.descriptionFil: Poklepovich, Tomás. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
dc.descriptionFil: Tolley, Charlotte. Wellcome Genome Campus. Wellcome Sanger Institute, Hinxton; Reino Unido.
dc.descriptionFil: Zolezzi, Gisella. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
dc.descriptionFil: Kane, Leanne. Wellcome Genome Campus. Wellcome Sanger Institute, Hinxton; Reino Unido.
dc.descriptionFil: Viñas, María Rosa. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
dc.descriptionFil: Panagópulo, Marcela. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
dc.descriptionFil: Moroni, Miriam. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
dc.descriptionFil: Binsztein, Norma. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
dc.descriptionFil: Caffer, María Inés. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
dc.descriptionFil: Clare, Simon. Wellcome Genome Campus. Wellcome Sanger Institute, Hinxton; Reino Unido.
dc.descriptionFil: Dougan, Gordon. Wellcome Genome Campus. Wellcome Sanger Institute, Hinxton; Reino Unido.
dc.descriptionFil: Salmond, George P. C. University of Cambridge. Department of Biochemistry, Cambridge; Reino Unido.
dc.descriptionFil: Parkhill, Julian. Wellcome Genome Campus. Wellcome Sanger Institute, Hinxton; Reino Unido.
dc.descriptionFil: Campos, Josefina. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
dc.descriptionFil: Thomson, Nicholas R. Wellcome Genome Campus. Wellcome Sanger Institute, Hinxton; Reino Unido.
dc.descriptionIn order to control and eradicate epidemic cholera, we need to understand how epidemics begin, how they spread, and how they decline and eventually end. This requires extensive sampling of epidemic disease over time, alongside the background of endemic disease that may exist concurrently with the epidemic. The unique circumstances surrounding the Argentinian cholera epidemic of 1992-1998 presented an opportunity to do this. Here, we use 490 Argentinian V. cholerae genome sequences to characterise the variation within, and between, epidemic and endemic V. cholerae. We show that, during the 1992-1998 cholera epidemic, the invariant epidemic clone co-existed alongside highly diverse members of the Vibrio cholerae species in Argentina, and we contrast the clonality of epidemic V. cholerae with the background diversity of local endemic bacteria. Our findings refine and add nuance to our genomic definitions of epidemic and endemic cholera, and are of direct relevance to controlling current and future cholera epidemics.
dc.formatpdf
dc.languageen
dc.relationNature communications
dc.rightsopen
dc.sourceNature Communications 2020; 11(1):4918
dc.subjectBacteriología
dc.subjectPatógenos Transmitidos por la Sangre
dc.subjectInfecciones Bacterianas
dc.titleGenomics of the Argentinian cholera epidemic elucidate the contrasting dynamics of epidemic and endemic Vibrio cholerae
dc.typeArtículo


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