Distinct monocyte subset phenotypes in patients with different clinical forms of chronic Chagas disease and seronegative dilated cardiomyopathy

Pérez-Mazliah, Damián E; Castro Eiro, Melisa D; Alvarez, María Gabriela; Lococo, Bruno; Bertocchi, Graciela; Cesar, Gonzalo; Natale, María Ailén; Albareda, María Cecilia; Viotti, Rodolfo; Laucella, Susana A.

Artículo

Registro en:

http://sgc.anlis.gob.ar/handle/123456789/1686

10.1371/journal.pntd.0006887

https://repositorioslatinoamericanos.uchile.cl/handle/2250/8519485

Autor

Pérez-Mazliah, Damián E

Castro Eiro, Melisa D

Alvarez, María Gabriela

Lococo, Bruno

Bertocchi, Graciela

Cesar, Gonzalo

Natale, María Ailén

Albareda, María Cecilia

Viotti, Rodolfo

Laucella, Susana A.

Institución

Administración Nacional de Laboratorios e Institutos de Salud (Argentina)

Resumen

Fil: Pérez-Mazliah, Damián E. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.

Fil: Castro Eiro, Melisa D. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.

Fil: Álvarez, María Gabriela. Hospital Interzonal General de Agudos Eva Perón; Argentina.

Fil: Lococo, Bruno. Hospital Interzonal General de Agudos Eva Perón; Argentina.

Fil: Bertocchi, Graciela. Hospital Interzonal General de Agudos Eva Perón; Argentina.

Fil: César, Gonzalo. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.

Fil: Natale, María A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.

Fil: Albareda, María C. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.

Fil: Viotti, Rodolfo. Hospital Interzonal General de Agudos Eva Perón; Argentina.

Fil: Laucella, Susana A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.

Chronic infection with Trypanosoma cruzi leads to a constant stimulation of the host immune system. Monocytes, which are recruited in response to inflammatory signals, are divided into classical CD14hiCD16-, non-classical CD14loCD16+ and intermediate CD14hiCD16+ subsets. In this study, we evaluated the frequencies of monocyte subsets in the different clinical stages of chronic Chagas disease in comparison with the monocyte profile of seronegative heart failure subjects and seronegative healthy controls. The effect of the anti-parasite drug therapy benznidazole on monocyte subsets was also explored.