Fil: Villar, Juan Carlos. Department of Medicine, Universidad Autónoma de Bucaramanga; Colombia.Fil: Perez, Juan Guillermo. Fundación Cardioinfantil Instituto de Cardiología, Bogota; Colombia.Fil: Cortes, Olga Lucia. Fundación Cardioinfantil Instituto de Cardiología, Bogota; ColombiaFil: Riarte, Adelina. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.Fil: Pepper, Micah. School of Public Health, Boston University, Boston; Estados Unidos.Fil: Marin-Neto, José Antônio. Medical School of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto; Brasil.Fil: Guyatt, Gordon H. Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton; Canada.Prevention of chronic chagasic cardiomyopathy (CCC) by treating infected populations with trypanocidal therapy (TT) remains a challenge. Despite a renewed enthusiasm for TT, uncertainty regarding its efficacy, concerns about its safety and limited availability remain barriers for a wider use of conventional drugs. We have updated a previous version of this review.