Phenotypic and Genotypic Characteristics of Neisseria meningitidis Disease-Causing Strains in Argentina, 2010

dc.creatorSorhouet Pereira, Cecilia
dc.creatorEfron, Adriana M.
dc.creatorGagetti, Paula
dc.creatorFaccone, Diego
dc.creatorRegueira, Mabel
dc.creatorCorso, Alejandra
dc.creatorGabastou, Jean-Marc
dc.creatorIbarz-Pavón, Ana Belén
dc.creatorGrupo SIREVA II
dc.date2013-05-11T18:45:24Z
dc.date2013-05-11T18:45:24Z
dc.date2013-03-04
dc.date.accessioned2023-08-29T20:04:10Z
dc.date.available2023-08-29T20:04:10Z
dc.identifier1932-6203
dc.identifierhttp://sgc.anlis.gob.ar/handle/123456789/483
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8517852
dc.descriptionFil: Sorhouet-Pereira, Cecilia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología. Servicio de Bacteriología Clínica; Argentina.
dc.descriptionFil: Efron, Adriana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología. Servicio de Bacteriología Clínica; Argentina.
dc.descriptionFil: Gagetti, Paula. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología. Servicio Antimicrobianos; Argentina.
dc.descriptionFil: Faccone, Diego. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología. Servicio Antimicrobianos; Argentina.
dc.descriptionFil: Regueira, Mabel. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología. Servicio de Bacteriología Clínica; Argentina.
dc.descriptionFil: Corso, Alejandra. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología. Servicio Antimicrobianos; Argentina.
dc.descriptionFil: Gabastou, Jean-Marc. Pan American Health Organization, Washington; Estados Unidos.
dc.descriptionFil: Ibarz-Pavón, Ana Belén. Pan American Health Organization, Washington; Estados Unidos.
dc.descriptionFil: Grupo SIREVA II; Argentina.
dc.descriptionPhenotypic and genotypic characterization of 133 isolates of Neisseria meningitidis obtained from meningococcal disease cases in Argentina during 2010 were performed by the National Reference Laboratory as part of a project coordinated by the PAHO within the SIREVA II network. Serogroup, serotype, serosubtype and MLST characterization were performed. Minimum Inhibitory Concentration to penicillin, ampicillin, ceftriaxone, rifampin, chloramphenicol, tetracycline and ciprofloxacin were determined and interpreted according to CLSI guidelines. Almost 49% of isolates were W135, and two serotype:serosubtype combinations, W135∶2a:P1.5,2:ST-11 and W135∶2a:P1.2:ST-11 accounted for 78% of all W135 isolates. Serogroup B accounted for 42.1% of isolates, and was both phenotypically and genotypically diverse. Serogroup C isolates represented 5.3% of the dataset, and one isolate belonging to the ST-198 complex was non-groupable. Isolates belonged mainly to the ST-11 complex (48%) and to a lesser extent to the ST-865 (18%), ST-32 (9,8%) and the ST-35 complexes (9%). Intermediate resistance to penicillin and ampicillin was detected in 35.4% and 33.1% of isolates respectively. Two W135∶2a:P1.5,2:ST-11:ST-11 isolates presented resistance to ciprofloxacin associated with a mutation in the QRDR of gyrA gene Thr91-Ile. These data show serogroup W135 was the first cause of disease in Argentina in 2010, and was strongly associated with the W135∶2a:P1.5,2:ST-11 epidemic clone. Serogroup B was the second cause of disease and isolates belonging to this serogroup were phenotypically and genotypically diverse. The presence of isolates with intermediate resistance to penicillin and the presence of fluorquinolone-resistant isolates highlight the necessity and importance of maintaining and strengthening National Surveillance Programs.
dc.formatpdf
dc.languageen
dc.rightsopen
dc.sourcePLoS One 2013;8(3):e58065
dc.subjectFenotipo
dc.subjectGenotipo
dc.subjectNeisseria meningitidis
dc.subjectEsguinces y Distensiones
dc.titlePhenotypic and Genotypic Characteristics of Neisseria meningitidis Disease-Causing Strains in Argentina, 2010
dc.typeArtículo


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