Trypanosoma cruzi: biological characterization of a isolate from an endemic area and its susceptibility to conventional drugs

dc.creatorGrosso, Noelia L.
dc.creatorBua, Jacqueline
dc.creatorPerrone, Alina E.
dc.creatorGonzalez, Mariela N.
dc.creatorBustos, Patricia L.
dc.creatorPostan, Miriam
dc.creatorFichera, Laura E.
dc.date2013-04-02T23:02:20Z
dc.date2013-04-02T23:02:20Z
dc.date2010
dc.date.accessioned2023-08-29T20:04:06Z
dc.date.available2023-08-29T20:04:06Z
dc.identifierhttp://sgc.anlis.gob.ar/handle/123456789/461
dc.identifier10.1016/j.exppara.2010.05.010
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8517816
dc.descriptionFil: Grosso, Noelia L. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
dc.descriptionFil: Bua, Jacqueline. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
dc.descriptionFil: Perrone, Alina E. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
dc.descriptionFil: Gonzalez, Mariela N. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
dc.descriptionFil: Bustos, Patricia L. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
dc.descriptionFil: Postan, Miriam. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
dc.descriptionFil: Fichera, Laura E. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
dc.descriptionWe describe some biological and molecular characteristics of a Trypanosoma cruzi isolate derived from a Triatomine captured in Nicaragua. PCR based typification showed that this isolate, named Nicaragua, belonged to the lineage Tc I. Nicaragua infected culture cells were treated with allopurinol, showing different behavior according to the cellular compartment, being cardiomyocyte primary cultures more resistant to this drug. The course of the infection in a mice experimental model and its susceptibility to benznidazole and allopurinol was analyzed. In benznidazole treatment, mice reverted the high lethal effect of parasites during the acute infection, however, a few parasites were detected in the heart of 88% of mice 1 year post-infection. Since T. cruzi is a heterogeneous species population it is important to study and characterize different parasites actually circulating in humans in endemic areas. In this work we show that T. cruzi Nicaragua isolate, is sensitive to early benznidazole treatment.
dc.formatpdf
dc.languageen
dc.publisherElsevier
dc.relationExperimental parasitology
dc.rightsopen
dc.sourceExperimental Parasitology 2010; 126(2): 239-244.
dc.subjectTrypanosoma cruzi
dc.subjectAlopurinol
dc.titleTrypanosoma cruzi: biological characterization of a isolate from an endemic area and its susceptibility to conventional drugs
dc.typeArtículo


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