| dc.creator | Fiorito, Paula | |
| dc.creator | Burgos, Juan M. | |
| dc.creator | Fernández-Miyakawa, Mariano E | |
| dc.creator | Rivas, Marta | |
| dc.creator | Chillemi, Germán | |
| dc.creator | Berkowski, Dario | |
| dc.creator | Zotta, Elsa | |
| dc.creator | Silberstein, Claudia | |
| dc.creator | Ibarra, Cristina | |
| dc.date | 2013-03-29T22:59:53Z | |
| dc.date | 2013-03-29T22:59:53Z | |
| dc.date | 2000 | |
| dc.date.accessioned | 2023-08-29T20:04:04Z | |
| dc.date.available | 2023-08-29T20:04:04Z | |
| dc.identifier | http://sgc.anlis.gob.ar/handle/123456789/451 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8517800 | |
| dc.description | Shiga toxin-producing Escherichia coli (STEC) colonize the lower segments of the human gastrointestinal tract, causing gastrointestinal and systemic diseases. In this study, the effects of Shiga toxin 2 (Stx2) on fluid absorption and ion transport in the human colon were examined. Net water movement (Jw) and short-circuit current (Isc) were simultaneously measured across the colonic mucosa incubated with crude or purified Stx2. Stx2 significantly inhibited the absorptive J(w) with no effect on the basal I-sc after 60 min of exposure. These effects may be due to the inhibition of a nonelectrogenic transport system present in the surface colonic villus cells. Morphological studies of the colonic mucosa treated with crude or purified Stx2 demonstrated a selective damage in the absorptive villus epithelial cells. These findings suggest that Stx2, inhibits water absorption across the human colon by acting on a specific cell population: the mature, differentiated absorptive villus epithelium. | |
| dc.rights | open | |
| dc.source | Digestive Diseases and Sciences, 45(3), 480-486. | |
| dc.title | Effect of Shiga toxin 2 on water and ion transport in human colon in vitro | |
