info:eu-repo/semantics/article
Huberine, a New Canthin-6-One Alkaloid from the Bark of Picrolemma huberi
Registro en:
López, C., Pastrana, M., Ríos, A., Cogollo, A. y Pabón, A. (2018). Huberine, un nuevo alcaloide Canthin-6-One de la corteza de Picrolemma huberi. Moléculas , 23 (4), 934. doi: 10.3390/moléculas23040934
10.3390/molecules23040934
1420-3049
Autor
López Córdoba, Carlos Alberto
Pastrana Restrepo, Manuel Humberto
Ríos Orrego, Alexandra Marcela
Cogollo Pacheco, Álvaro Alfonso
Pabón Vidal, Adriana Lucía
Institución
Resumen
ABSTRACT: A new alkaloid, Canthin-6-one, Huberine (1), together with three known compounds including 1-Hydroxy-canthin-6-one (2), Canthin-6-one (3) and stigma sterol (4), were isolated from the stem bark of Picrolemma huberi. The isolation was achieved by chromatographic techniques and the purification was performed on a C18 column using acetonitrile/water (90:10, v/v) with 0.1% formic acid as the mobile phase. The structural elucidation was performed via spectroscopic methods, notably 1D- and 2D-NMR, UV, IR, MS and HRMS. The antiplasmodial activity of the compounds was studied. COL0007524 COL0000461