info:eu-repo/semantics/article
Hepatitis B and Hepatitis C Infection Biomarkers and TP53 Mutations in Hepatocellular Carcinomas from Colombia
Registro en:
2090-1364
10.1155/2011/582945
2090-1372
Autor
Navas Navas, María Cristina
Suárez Mellado, Iris
Carreño Vanegas, Andrea Fernanda
Uribe Yunda, Diego Fernando
Ríos Ocampo, Wilson Alfredo
Cortés Mancera, Fabián Mauricio
Martel, Ghyslaine
Vieco, Beatriz
Lozano, Diana
Jiménez, Carlos
Gouas, Doriane
Osorio, Germán
Hoyos Duque, Sergio Iván
Restrepo, Juan C.
Correa Arango, Gonzalo
Jaramillo, Sergio
Lopez, Rocío
Bravo, Luis E.
Arbeláez Montoya, María Patricia
Scoazec, Jean Y.
Abedi Ardekani, Behnoush
Santella, Regina M.
Chemin, Isabelle
Hainaut, Pierre
Institución
Resumen
ABSTRACT: Hepatocellular Carcinoma (HCC) is a leading cause of cancer-related death worldwide. Globally, the most important HCC risk factors are Hepatitis B Virus (HBV) and/or Hepatitis C Virus (HCV), chronic alcoholism, and dietary exposure to aflatoxins. We have described the epidemiological pattern of 202 HCC samples obtained from Colombian patients. Additionally we investigated HBV/HCV infections and TP53 mutations in 49 of these HCC cases. HBV biomarkers were detected in 58.1% of the cases; HBV genotypes F and D were characterized in three of the samples. The HCV biomarker was detected in 37% of the samples while HBV/HCV coinfection was found in 19.2%. Among TP53 mutations, 10.5% occur at the common aflatoxin mutation hotspot, codon 249. No data regarding chronic alcoholism was available from the cases. In conclusion, in this first study of HCC and biomarkers in a Colombian population, the main HCC risk factor was HBV infection. COL0024159 COL0004362