Increased hippocampal, thalamus and amygdala volume in long-term lithium treated Bipolar I Disorder patients compared with unmedicated patients and healthy subjects

dc.creatorLópez Jaramillo, Carlos Alberto
dc.creatorVargas Upegui, Cristian David
dc.creatorDíaz Zuluaga, Ana María
dc.creatorPalacio Ortiz, Juan David
dc.creatorCastrillón, Gabriel
dc.creatorBearden, Carrie
dc.creatorVieta, Eduard
dc.date2022-07-13T19:20:08Z
dc.date2022-07-13T19:20:08Z
dc.date2017
dc.date.accessioned2023-08-28T19:53:43Z
dc.date.available2023-08-28T19:53:43Z
dc.identifier1398-5647
dc.identifierhttps://hdl.handle.net/10495/29714
dc.identifier10.1111/bdi.12467
dc.identifier1399-5618
dc.identifierhttps://onlinelibrary.wiley.com/doi/epdf/10.1111/bdi.1246710.1111/bdi.12467
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8470420
dc.descriptionABSTRACT: Objective: Magnetic resonance imaging (MRI) studies in bipolar I disorder (BD-I) suggest that lithium is associated with increased volumes of cortico-limbic structures. However, more rigorous control of confounding factors is needed to obtain further support for this hypothesis. The aim of the present study was to assess differences in brain volumes among long-term lithium-treated BD-I patients, unmedicated BD-I patients, and healthy controls. Methods: This was a cross-sectional study with 32 euthymic BD-I patients (16 on lithium monotherapy for a mean of 180 months, and 16 receiving no medication for at least the 2 months prior to the study) and 20 healthy controls. Patients were euthymic (Hamilton Depression Rating Scale [HDRS] <6 and Young Mania Rating Scale [YMRS] <7) and had not taken psychotropic medications other than lithium for at least 6 months. Brain images were acquired on a 1.5 Tesla MRI (Phillips, Amsterdam, The Netherlands) and segmented to generate volumetric measures of cortical and subcortical brain areas, ventricles and global brain. Results: Significant differences were found in the volumes of the left amygdala (P=.0003), right amygdala (P=.030), left hippocampus (P=.022), left thalamus (P=.022), and right thalamus (P=.019) in long-term lithium-treated BD-I patients, compared to unmedicated patients and controls, after multivariable adjustment. No differences were observed in global brain volume or in ventricular size among the three groups. Likewise, there was no correlation between serum lithium levels and the increase in size in the described brain areas. Conclusions: The structural differences found among the three groups, and specifically those between long-term lithium-treated and unmedicated BD-I patients, indicate increased limbic structure volumes in lithium-treated patients.
dc.description0029147
dc.format9
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherWiley
dc.publisherGrupo de Investigación en Psiquiatría GIPSI
dc.publisherCopenhague, Dinamarca
dc.relationBipolar Disord
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectBipolar Disorder
dc.subjectTrastorno Bipolar
dc.subjectLithium
dc.subjectLitio
dc.subjectNeuroimaging
dc.subjectNeuroimagen
dc.titleIncreased hippocampal, thalamus and amygdala volume in long-term lithium treated Bipolar I Disorder patients compared with unmedicated patients and healthy subjects
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typehttp://purl.org/coar/resource_type/c_2df8fbb1
dc.typehttps://purl.org/redcol/resource_type/ART
dc.typeArtículo de investigación


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