Antibody Response to Plasmodium Vivax Antigens in Fy-Negative Individuals From the Colombian Pacific Coast

dc.creatorHerrera Valencia, Socrates
dc.creatorGómez, Andrés
dc.creatorVera Lezcano, Omaira
dc.creatorVergara, Juana
dc.creatorValderrama Aguirre, Augusto
dc.creatorMaestre Buitrago, Amanda Elena
dc.creatorMéndez Paz, Fabian
dc.creatorWang, Ruibing
dc.creatorChitnis, Chetan E
dc.creatorYazdani, Syed S
dc.creatorArévalo Herrera, Myriam
dc.date2021-08-01T13:41:04Z
dc.date2021-08-01T13:41:04Z
dc.date2005
dc.date.accessioned2023-08-28T19:37:49Z
dc.date.available2023-08-28T19:37:49Z
dc.identifierHerrera, S., Gómez, A., Vera, O., Vergara, J., Valderrama-Aguirre, A., Maestre, A., Méndez, F., Wang, R., Chitnis, C. E., Yazdani, S. S., & Arévalo-Herrera, M. (2005). Antibody Response to Plasmodium Vivax Antigens in Fy-Negative Individuals From the Colombian Pacific Coast, The American Journal of Tropical Medicine and Hygiene Am J Trop Med Hyg, 73(5_suppl), 44-49. Retrieved Aug 1, 2021, from https://www.ajtmh.org/view/journals/tpmd/73/5_suppl/article-p44.xml
dc.identifier0002-9637
dc.identifierhttp://hdl.handle.net/10495/21376
dc.identifier10.4269/ajtmh.2005.73.44
dc.identifier1476-1645
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8465285
dc.descriptionABSTRACT: The Duffy antigen (Fy) is necessary for Plasmodium vivax invasion of human erythrocytes. Some populations have a highly prevalent Fy-negative phenotype; such persons are naturally protected from P. vivax blood infection but are expected to completely support the P. vivax pre-erythrocytic cycle, representing a valuable model for studying the immune response during these parasitic stages. We typed 214 individuals, mostly Afro-Colombians, from a P. vivax-endemic area for Fy expression and determined the antibody response to P. vivax pre-erythrocytic (sporozoites and CS) and blood-stage antigens (blood forms, P. vivax merozoite surface protein 1, and P. vivax Duffy binding protein [PvDBP]). Antibody titers to P. vivax circumsporozoite protein, P11, and N-terminal peptides and the number of responders were similar in Fy-negative and Fy-positive individuals. The number of responders to sporozoites, blood forms, and PvDBP were different between these groups. Thus, Fy-negative individuals from malaria-endemic areas can be used to study the immune response to the P. vivax liver phase without interference of the erythrocytic cycle
dc.descriptionCOL0047449
dc.format6
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherAmerican Society of Tropical Medicine and Hygiene
dc.publisherGrupo Malaria
dc.publisherBaltimore, Estados Unidos
dc.relationAm. J. Trop. Med. Hyg.
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by/2.5/co/
dc.rightshttp://purl.org/coar/access_right/c_abf2
dc.rightshttps://creativecommons.org/licenses/by/4.0/
dc.subjectMalaria
dc.subjectPlasmodium vivax
dc.subjectAntígenos
dc.subjectAntigens
dc.titleAntibody Response to Plasmodium Vivax Antigens in Fy-Negative Individuals From the Colombian Pacific Coast
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typehttp://purl.org/coar/resource_type/c_2df8fbb1
dc.typehttps://purl.org/redcol/resource_type/ART
dc.typeArtículo de investigación


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