info:eu-repo/semantics/article
Characterization of the venom of C. d. cumanesis of Colombia : Proteomic analysis and antivenomic study
Registro en:
10.3390/toxins10020085
2072-6651
Autor
Quintana Castillo, Juan Carlos
Vargas Muñoz, Leidy Johana
Segura Latorre, Cesar
Estrada Gómez, Sebastian
Bueno Sánchez, Julio César
Alarcón Pérez, Juan Carlos
Institución
Resumen
ABSTRACT: The Colombian rattlesnake Crotalus durissus cumanensis is distributed in three geographic
zones of the country: the Atlantic Coast, the upper valley of the Magdalena River, and the eastern plains of the Colombian Orinoquía. Its venom induces neurological symptoms, such as eyelid ptosis, myasthenic facies, and paralysis of the respiratory muscles, which can lead to death. Identification and analysis of C. d. cumanensis showed nine groups of proteins responsible for the neurotoxic effect, of which the crotoxin complex was the most abundant (64.71%). Immunorecognition tests of C. d. cumanensis showed that the use of a commercial antivenom manufactured in Mexico resulted in immunoreactivity. COL0007631 COL0007524 COL0014476