56 p. Recurso Electr?nicoLa osteoartritis es una patolog?a que afecta frecuentemente las articulaciones implicando da?os en el hueso subcondral. El objetivo de este trabajo fue evaluar el efecto de la aplicaci?n del concentrado aut?logo de plaquetas (CAP) en lesiones experimentales a nivel del hueso subcondral en la articulaci?n femoro-tibio-patelar en conejos (Oryctolagus cuniculus). Se utilizaron 15 conejos machos, adultos j?venes, de raza Nueva Zelanda. Cada animal fue intervenido quir?rgicamente en ambas rodillas bajo anestesia inhalatoria. Se efectu? una lesi?n experimental de 5 mm en el c?ndilo medial del f?mur, a la rodilla derecha se le aplic? soluci?n salina fisiol?gica y a la contralateral se le aplic? CAP. La eutanasia de los animales se realiz? en los tres tiempos de evaluaci?n as?: a los 30, 60 y 90 d?as posquir?rgico y cada grupo cont? con cinco conejos respectivamente, a los que se les extrajo la regi?n ?sea donde se realiz? el defecto experimental. Para el estudio histopatol?gico las muestras fueron descalcificadas en una soluci?n comercial a base de ?cido f?rmico, luego fueron procesadas de forma rutinaria. Se emple? la tinci?n de hematoxilina y eosina, tricr?mico de Masson y picrosirius rojo. Se realiz? an?lisis histomorfom?trico a todas las muestras y los resultados fueron sometidos a pruebas estad?sticas. El uso del CAP en la reparaci?n ?sea no fue estad?sticamente significativo. Aun as?, los an?lisis histol?gicos, sugieren que la precocidad en la proliferaci?n y diferenciaci?n de condroblastos es influenciada por el CAP, lo que favorece la osificaci?n. Palabras Claves: concentrado aut?logo de plaquetas, hueso subcondral, reparaci?n ?sea.Osteoarthritis is a pathology that frequently affects the joints, causing degeneration in the subchondral bone. The aim of the following research was to evaluate the effect of the application of Autologous Platelets Concentrate (APC) in experimental injuries at the subchondral bone level in the femoro-tibio-patellar joint in rabbits (Oryctolagus cuniculus). Fifteen young male adult New Zealand rabbits were used for the experimental purpose. In each animal, both pelvic limbs were surgically intervened under inhalation anesthesia. An experimental 5 mm injury was performed with a surgical drill on the medial condyle of the femur; physiological saline was applied to the right pelvic member and APC was applied to the contralateral limb. Euthanasia of the animals was carried out in three groups: at 30, 60 and 90 days post-surgery and each group had five rabbits respectively, from which the bone region, where the experimental defect was made, was extracted. For the histopathological study, the samples were decalcified in a commercial product based on formic acid to then be processed routinely. Hematoxylin and eosin staining, Masson?s trichrome and red picrosirius were used to color the tissues. Histomorphometric analysis was performed on all samples and the results were subjected to statistical tests. The use of APC in bone repair was not statistically significant. However, histological analyzes suggest that precocity in the proliferation and differentiation of chondroblasts is influenced by APC, which favors the early mineralization of the cartilaginous matrix. Keywords: autologous platelets concentrate, bone repair, subchondral bone.