Audios
Biomolecular engineering: general concepts: part 1 [Frontiers of biomedical engineering]
Autor
Saltzman, W. Mark
Resumen
Educação Superior::Engenharias::Engenharia Biomédica Educação Superior::Ciências da Saúde::Farmácia Presents a class where Professor Saltzman starts the lecture with an introduction to pharmacokinetics and pharmacodynamics. Professor Saltzman talks about the concept of dose-response. He introduces different routes of drug administration and how they affect drug distribution and bioavailability (i.e., intravenous, oral, and sublingual routes). First-pass drug metabolism by the liver is also identified as an important source of drug degradation. Finally, modeling the body as a well-stirred vessel, Professor Saltzman explains the first-order rate equation: C = (M0/V)*e-kt, that can be used calculate the amount of drug in the body (M) as a function of time (t) and a rate constant (k); and the equation for drug half-life: t = ln(2/k)