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        Exploring the relationship between the Gut Microbiota and Ageing: A possible age modulator

        Fecha
        2023
        Registro en:
        Salazar, J.; Durán, P.; Díaz, M.P.; Chacín, M.; Santeliz, R.; Mengual, E.; Gutiérrez, E.; León, X.; Díaz, A.; Bernal, M.; et al. Exploring the Relationship between the Gut Microbiota and Ageing: A Possible Age Modulator. Int. J. Environ. Res. Public Health 2023, 20, 5845. https://doi.org/10.3390/ijerph20105845
        16604601
        https://hdl.handle.net/20.500.12442/13165
        https://doi.org/10.3390/ijerph20105845
        https://repositorioslatinoamericanos.uchile.cl/handle/2250/8356780
        Autor
        Salazar, Juan
        Durán, Pablo
        Díaz, María P.
        Chacín, Maricarmen
        Santeliz, Raquel
        Mengual, Edgardo
        Gutiérrez, Emma
        León, Xavier
        Díaz, Andrea
        Bernal, Marycarlota
        Escalona, Daniel
        Parra Hernández, Luis Alberto
        Bermúdez, Valmore
        Institución
        • Universidad Simón Bolívar (Colombia)
        Resumen
        The gut microbiota (GM) has been the subject of intense research in recent years. Therefore, numerous factors affecting its composition have been thoroughly examined, and with them, their function and role in the individual’s systems. The gut microbiota’s taxonomical composition dramatically impacts older adults’ health status. In this regard, it could either extend their life expectancy via the modulation of metabolic processes and the immune system or, in the case of dysbiosis, predispose them to age-related diseases, including bowel inflammatory and musculoskeletal diseases and metabolic and neurological disorders. In general, the microbiome of the elderly tends to present taxonomic and functional changes, which can function as a target to modulate the microbiota and improve the health of this population. The GM of centenarians is unique, with the faculty-promoting metabolic pathways capable of preventing and counteracting the different processes associated with age-related diseases. The molecular mechanisms by which the microbiota can exhibit anti-ageing properties are mainly based on anti-inflammatory and antioxidant actions. This review focuses on analysing the current knowledge of gut microbiota characteristics and modifiers, its relationship with ageing, and the GM-modulating approaches to increase life expectancy.
        Materias
        Gut microbiota
        Ageing
        Longevity
        Immune system
        Centenarian

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        Red de Repositorios Latinoamericanos
        + de 8.000.000 publicaciones disponibles
        500 instituciones participantes
        Dirección de Servicios de Información y Bibliotecas (SISIB)
        Universidad de Chile
        Ingreso Administradores
        Colecciones destacadas
        • Tesis latinoamericanas
        • Tesis argentinas
        • Tesis chilenas
        • Tesis peruanas
        Nuevas incorporaciones
        • Argentina
        • Brasil
        • Colombia
        • México
        Dirección de Servicios de Información y Bibliotecas (SISIB)
        Universidad de Chile
        Red de Repositorios Latinoamericanos | 2006-2018